PXD020237-1

PXD020237 is an original dataset announced via ProteomeXchange.

Title	Combined Peptidomic and Proteomic analysis of OSCC Saliva
Description	Protease activity has been associated with pathological processes that can lead to cancer development and progression. However, understanding the pathological unbalance in proteolysis is challenging since changes can occur simultaneously at protease, their inhibitor and substrate levels. In this work we combined peptidomics, proteomics and peptidase predictions for studying proteolytic events in saliva associated with oral squamous cell carcinoma (OSCC) prognosis. Our results suggest that cleavage products differentially abundant in the saliva of patients with (N+) or without (N0) nodal metastasis exhibit potential of prognostic value in oral cancer and were are able to discriminate N+ and N0 patients whereas reduced protein levels of peptidase inhibitors might disturb the proteolytic balance in saliva of OSCC patients with poor prognosis
HostingRepository	PanoramaPublic
AnnounceDate	2020-11-12
AnnouncementXML	Submission_2020-11-12_13:24:55.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	supported by repository but incomplete data and/or metadata
PrimarySubmitter	Adriana Paes Leme
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	Label:13C(6)15N(2); Label:13C(6)15N(4)
Instrument	Xevo TQ-XS; ACQUITY UPLC

Revision	Datetime	Status	ChangeLog Entry
0	2020-07-07 07:43:39	ID requested
⏵ 1	2020-11-12 13:24:56	announced

submitter keyword: saliva, oral cancer, peptidome, proteolysis, protease inhibitors, oral squamous cell carcinoma

Adriana Paes Leme
contact affiliation	National Laboratory of Biosciences-CNPEM. Brazil
contact email	adriana.paesleme@lnbio.cnpem.br
lab head
Adriana Paes Leme
contact affiliation	National Laboratory of Biosciences-CNPEM. Brazil
contact email	adriana.paesleme@lnbio.cnpem.br
dataset submitter

Panorama Public dataset URI