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PXD020237

PXD020237 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleCombined Peptidomic and Proteomic analysis of OSCC Saliva
DescriptionProtease activity has been associated with pathological processes that can lead to cancer development and progression. However, understanding the pathological unbalance in proteolysis is challenging since changes can occur simultaneously at protease, their inhibitor and substrate levels. In this work we combined peptidomics, proteomics and peptidase predictions for studying proteolytic events in saliva associated with oral squamous cell carcinoma (OSCC) prognosis. Our results suggest that cleavage products differentially abundant in the saliva of patients with (N+) or without (N0) nodal metastasis exhibit potential of prognostic value in oral cancer and were are able to discriminate N+ and N0 patients whereas reduced protein levels of peptidase inhibitors might disturb the proteolytic balance in saliva of OSCC patients with poor prognosis
HostingRepositoryPanoramaPublic
AnnounceDate2020-11-12
AnnouncementXMLSubmission_2020-11-12_13:24:55.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportsupported by repository but incomplete data and/or metadata
PrimarySubmitterAdriana Paes Leme
SpeciesList scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationListLabel:13C(6)15N(2); Label:13C(6)15N(4)
InstrumentXevo TQ-XS; ACQUITY UPLC
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-07-07 07:43:39ID requested
12020-11-12 13:24:56announced
Publication List
Neves LX, Granato DC, Busso-Lopes AF, Carnielli CM, Patroni FMS, De Rossi T, Oliveira AK, Ribeiro ACP, Brandão TB, Rodrigues AN, Lacerda PA, Uno M, Cervigne NK, Santos-Silva AR, Kowalski LP, Lopes MA, Leme AFP, Peptidomics-driven strategy reveals peptides and predicted proteases associated with oral cancer prognosis. Mol Cell Proteomics, ():(2020) [pubmed]
Keyword List
submitter keyword: saliva, oral cancer, peptidome, proteolysis, protease inhibitors, oral squamous cell carcinoma
Contact List
Adriana Paes Leme
contact affiliationNational Laboratory of Biosciences-CNPEM. Brazil
contact emailadriana.paesleme@lnbio.cnpem.br
lab head
Adriana Paes Leme
contact affiliationNational Laboratory of Biosciences-CNPEM. Brazil
contact emailadriana.paesleme@lnbio.cnpem.br
dataset submitter
Full Dataset Link List
Panorama Public dataset URI