PXD019810-1

PXD019810 is an original dataset announced via ProteomeXchange.

Title	HDX-MS of VDR-RXR in complex with ZK168281
Description	Characterization of the interaction between the full nuclear receptor VDR-RXR heterodimer and VDR antagonist ZK168281
HostingRepository	PRIDE
AnnounceDate	2020-12-16
AnnouncementXML	Submission_2020-12-15_22:43:21.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Anna Belorusova
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Synapt MS

Revision	Datetime	Status	ChangeLog Entry
0	2020-06-16 08:30:44	ID requested
⏵ 1	2020-12-15 22:43:22	announced

Rovito D, Belorusova AY, Chalhoub S, Rerra AI, Guiot E, Molin A, Linglart A, Rochel N, Laverny G, Metzger D, Cytosolic sequestration of the vitamin D receptor as a therapeutic option for vitamin D-induced hypercalcemia. Nat Commun, 11(1):6249(2020) [pubmed]

submitter keyword: HDX-MS, nuclear receptors, antagonist

Tomas Leek
contact affiliation	Medicinal Chemistry, Early Respiratory and Immunology, Biopharmaceuticals R&D, AstraZeneca
contact email	Tomas.Leek@astrazeneca.com
lab head
Anna Belorusova
contact affiliation	Medicinal Chemistry, Early Respiratory and Inflammation, BioPharmaceuticals R&D, AstraZeneca
contact email	anna.y.belorusova@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/12/PXD019810

PRIDE project URI

• PRIDE
  1. PXD019810
     1. Label: PRIDE project
     2. Name: HDX-MS of VDR-RXR in complex with ZK168281