PXD019498-1

PXD019498 is an original dataset announced via ProteomeXchange.

Title	p53 amyloid induced cellular transformation and tumor formation in the mouse xenograft model
Description	p53 amyloid formation is predicted to be involved in cancer initiation, but the direct evidence of how altered p53 acts as an oncogene is lacking. Cells with p53 amyloids show enhanced survival, apoptotic resistance with increased proliferation and migration rates. Proteomic profiling of cells containing p53 aggregates suggests that p53 amyloid formation triggers aberrant expression of pro-oncogenes while downregulating the tumor-suppressive genes. We propose that wild-type p53 amyloid formation can potentially contribute to the initiation of tumor development.
HostingRepository	PRIDE
AnnounceDate	2022-07-16
AnnouncementXML	Submission_2022-07-15_23:48:38.034.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Tushar Maiti
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iTRAQ8plex-116 reporter+balance reagent acylated residue; iodoacetamide derivatized residue
Instrument	TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2020-06-01 16:55:05	ID requested
⏵ 1	2022-07-15 23:48:38	announced

Navalkar A, Paul A, Sakunthala A, Pandey S, Dey AK, Saha S, Sahoo S, Jolly MK, Maiti TK, Maji SK, Oncogenic gain of function due to p53 amyloids occurs through aberrant alteration of cell cycle and proliferation. J Cell Sci, 135(15):(2022) [pubmed]

submitter keyword: p53, amyloid, cancer initiation, tumorigenesis, Isobaric tags for relative and absolute quantitation (iTRAQ)

Dr Tushar Kanti Maiti
contact affiliation	Associate Professor Regional Centre for Biotechnology
contact email	tkmaiti@rcb.res.in
lab head
Tushar Maiti
contact affiliation	Regional Centre for Biotechnology
contact email	tkmaiti@rcb.res.in
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/07/PXD019498

PRIDE project URI

• PRIDE
  1. PXD019498
     1. Label: PRIDE project
     2. Name: p53 amyloid induced cellular transformation and tumor formation in the mouse xenograft model