PXD019498 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | p53 amyloid induced cellular transformation and tumor formation in the mouse xenograft model |
Description | p53 amyloid formation is predicted to be involved in cancer initiation, but the direct evidence of how altered p53 acts as an oncogene is lacking. Cells with p53 amyloids show enhanced survival, apoptotic resistance with increased proliferation and migration rates. Proteomic profiling of cells containing p53 aggregates suggests that p53 amyloid formation triggers aberrant expression of pro-oncogenes while downregulating the tumor-suppressive genes. We propose that wild-type p53 amyloid formation can potentially contribute to the initiation of tumor development. |
HostingRepository | PRIDE |
AnnounceDate | 2022-07-16 |
AnnouncementXML | Submission_2022-07-15_23:48:38.034.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Tushar Maiti |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | iTRAQ8plex-116 reporter+balance reagent acylated residue; iodoacetamide derivatized residue |
Instrument | TripleTOF 5600 |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2020-06-01 16:55:05 | ID requested | |
⏵ 1 | 2022-07-15 23:48:38 | announced | |
Publication List
Navalkar A, Paul A, Sakunthala A, Pandey S, Dey AK, Saha S, Sahoo S, Jolly MK, Maiti TK, Maji SK, Oncogenic gain of function due to p53 amyloids occurs through aberrant alteration of cell cycle and proliferation. J Cell Sci, 135(15):(2022) [pubmed] |
Keyword List
submitter keyword: p53, amyloid, cancer initiation, tumorigenesis, Isobaric tags for relative and absolute quantitation (iTRAQ) |
Contact List
Dr Tushar Kanti Maiti |
contact affiliation | Associate Professor Regional Centre for Biotechnology |
contact email | tkmaiti@rcb.res.in |
lab head | |
Tushar Maiti |
contact affiliation | Regional Centre for Biotechnology |
contact email | tkmaiti@rcb.res.in |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/07/PXD019498 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD019498
- Label: PRIDE project
- Name: p53 amyloid induced cellular transformation and tumor formation in the mouse xenograft model