<<< Full experiment listing

PXD019399-1

PXD019399 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleThe Caveolin3 complex stabilizes functional surface expression of the Lactate-Proton Shuttle McT1 but not the sodium channel Nav1.5 in cardiomyocytes - Part 3: Cav1/Cav3 Interactome
DescriptionCaveolin3 variants were associated with action potential prolongation. As Caveolin1 was recently identified in cardiomyocytes, we hypothesize that conserved isoform-specific protein interactions underlie human loss-of-function variants. To analyze the Caveolin1 and Caveolin3 interactome, we developed unbiased live-cell proteomic and isoform-specific mass spectrometry techniques. We demonstrate the functional relevance and pathogenic mechanism of a novel Caveolin3 interactor in gene-edited human iPSC-cardiomyocyte models.
HostingRepositoryPRIDE
AnnounceDate2022-10-30
AnnouncementXMLSubmission_2022-10-30_08:39:03.939.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterChristofLenz
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListNo PTMs are included in the dataset
InstrumentTripleTOF 5600
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-05-26 17:41:37ID requested
12022-10-30 08:39:04announced
22023-11-14 08:50:52announced2023-11-14: Updated project metadata.
Publication List
Keyword List
submitter keyword: cardiomyopathy
cell biology
metabolism
proteomics
stem cells
Contact List
ChristofLenz
contact affiliationInstitute of Clinical Chemistry, University Medical Center Goettingen
contact emailchristof.lenz@mpibpc.mpg.de
lab head
ChristofLenz
contact affiliationMax Planck Institute for Biophysical Chemistry
contact emailchristof.lenz@mpibpc.mpg.de
dataset submitter
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/10/PXD019399
PRIDE project URI
Repository Record List
[ + ]