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PXD019221 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProteomic and Metabolomic Characterization of COVID-19 Patient Sera
DescriptionEarly detection and effective treatment of severe COVID-19 patients remain major challenges. Here, we performed proteomic and metabolomic profiling of sera from 46 COVID-19 and 53 control individuals. We then trained a machine learning model using proteomic and metabolomic measurements from a training cohort of 18 non-severe and 13 severe patients. The model was validated using ten independent patients, seven of which were correctly classified. Targeted proteomics and metabolomics assays were employed to further validate this molecular classifier in a second test cohort of 19 new COVID-19 patients, leading to 16 correct assignments. We identified molecular changes in the sera of COVID-19 patients compared to other groups implicating dysregulation of macrophage, platelet degranulation and complement system pathways, and massive metabolic suppression. This study revealed characteristic protein and metabolite changes in the sera of severe COVID-19 patients, which might be used in selection of potential blood biomarkers for severity evaluation.
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterTiannan Guo
SpeciesList scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-05-15 08:05:55ID requested
12020-05-16 04:46:49announced
22020-08-04 19:50:37announced2020-08-05: Update publication information
Publication List
Shen B, Yi X, Sun Y, Bi X, Du J, Zhang C, Quan S, Zhang F, Sun R, Qian L, Ge W, Liu W, Liang S, Chen H, Zhang Y, Li J, Xu J, He Z, Chen B, Wang J, Yan H, Zheng Y, Wang D, Zhu J, Kong Z, Kang Z, Liang X, Ding X, Ruan G, Xiang N, Cai X, Gao H, Li L, Li S, Xiao Q, Lu T, Zhu Y, Liu H, Chen H, Guo T, Proteomic and Metabolomic Characterization of COVID-19 Patient Sera. Cell, 182(1):59-72.e15(2020) [pubmed]
Keyword List
submitter keyword: COVID-19, Proteomics, Metabolomics, Severity
Contact List
Tiannan Guo
contact affiliationWestlake University
contact emailguotiannan@westlake.edu.cn
lab head
Tiannan Guo
contact affiliationWestlake University
contact emailguotiannan@westlake.edu.cn
dataset submitter
Full Dataset Link List
iProX dataset URI