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PXD018958-1

PXD018958 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleBlood circulation of soft nanomaterials is governed by dynamic remodeling of protein opsonins at nanobiointerface
DescriptionNanomaterials in blood must mitigate the immune response to have prolonged residency, a property that is highly relevant to biocompatibility, toxicity, and the generation of long acting therapeutics. The composition of the protein corona that forms at the nano-biointerface may be directing this, however, it is currently unknown the possible correlation of corona composition with blood residency. We developed a panel of new soft single molecule polymer nanomaterials (SMPNs) with varying circulation times in mice (t1/2 ~22 to 65 h) and used proteomics to probe the nano-biointerface to elucidate the mechanism of blood residency of nanomaterials. The composition of the protein opsonins on SMPNs was qualitatively and quantitatively dynamic with time in circulation, and SMPNs that circulated longer were able to clear some of the initial surface-bound common opsonins, including immunoglobulins, complement, and coagulation proteins. This continuous remodelling of protein opsonins, a phenomenon first of its kind observed, may be a decisive step in directing elimination or residence of the reported soft nanomaterials in vivo.
HostingRepositoryMassIVE
AnnounceDate2020-05-13
AnnouncementXMLSubmission_2020-05-13_15:00:57.xml
DigitalObjectIdentifier
ReviewLevelNon peer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterJason Rogalski
SpeciesList scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090;
ModificationListOxidation; Acetyl
Instrumentinstrument model
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-05-03 12:27:32ID requested
12020-05-13 15:00:57announced
Publication List
no publication
Keyword List
submitter keyword: Circulating nanoparticle
Contact List
Jayachandran N. Kizhakkedathu
contact affiliationUniversity of British Columbia
contact emailjay@pathology.ubc.ca
lab head
Jason Rogalski
contact affiliationUBC
contact emailrogy@mail.ubc.ca
dataset submitter
Full Dataset Link List
MassIVE dataset URI
Dataset FTP location
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