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PXD018848-1

PXD018848 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleSystematic Analysis of the Lysine Crotonylome and multiple PTM analysis (acetylation, succinylation and crotonylation) in Candida albicans
DescriptionLC-MS/MS was used to carry out the analysis of the crotonylome in C. albicans (Candida albicans) comprehensively in our study. Generally, 5242 specific crotonylated sites of 1584 crotonylated proteins were detected among 9038 proteins in C. albicans. The crotonylome involved in the regulation of metabolism through the bioinformatics analysis. Moreover, the crotonylated proteins related to biosynthesis and carbon metabolism were prevalence phenomenon. Moreover, a universal rule were found in crotonylated motifs: D/E were found in the position (+1, +2 or +3) and K/R were found in the position (+5 or +6) of the residue; A/E/F/G/P/W/Y were found in the -1 position and A/K/R were found in the position (-5, -6, -7 or -8) of the residue. As far as we know, crotonylated histone sites that screened in C. albicans of this study have not been reported before. Furthermore, a variety of connections in PPI (protein-protein interaction network) of ribosome, oxidative phosphorylation, nucleus and proteasome were modified by acetylation, succinylation and crotonylation. Sir2 inhibitor AK-1 was able to promote histone lysine crotonylation and non-histone lysine crotonylation.
HostingRepositoryPRIDE
AnnounceDate2021-01-08
AnnouncementXMLSubmission_2021-01-08_00:00:49.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterxiaowei zhou
SpeciesList scientific name: Candida albicans; NCBI TaxID: 5476;
ModificationListN6-crotonyl-L-lysine
InstrumentQ Exactive HF-X
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-04-28 01:09:40ID requested
12021-01-08 00:00:49announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: C. albicans
Crotonylome
Histone
Lysine crotonylation motif
PPI
Contact List
Xiaofang Li
contact affiliationDepartment of Medical Mycology, Institute of Dermatology, Chinese Academy of Medical Science and Peking Union Medical College; Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing 210042, China
contact emailzhouxw@pumcderm.cams.cn
lab head
xiaowei zhou
contact affiliationDepartment of Medical Mycology, Institute of Dermatology, Chinese Academy of Medical Science and Peking Union Medical College; Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs
contact emailzhouxw@pumcderm.cams.cn
dataset submitter
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