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PXD018357 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleInhibition of growth factor signaling prevents SARS-CoV-2 replication
DescriptionCaco-2 cells were mock-infected or infected with SARS-CoV-2 patient isolates (in biological quintruplicates) for one hour, washed, and incubated for 24 hours before cell harvest. Extracted proteins were digested and split to 1) carry out whole-cell proteomics of a tandem mass tag (TMT) 10-plex samples using liquid chromatography synchronous precursor selection mass spectromety (LC-SPS-MS3), or 2) use Fe-NTA phosphopeptide enrichment (achieving 98% enrichment) for phospho proteome analyses of a TMT 10-plex analyzed by LC-MS2 First 5 channels = control Last 5 channels = infected
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterKevin Klann
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListTMT6plex-126 reporter+balance reagent acylated residue; phosphorylated residue; monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-04-04 07:43:48ID requested
12020-05-15 00:23:09announced
22020-09-25 03:11:02announced2020-09-25: Updated publication reference for PubMed record(s): 32877642.
Publication List
Klann K, Bojkova D, Tascher G, Ciesek S, Münch C, Cinatl J, Growth Factor Receptor Signaling Inhibition Prevents SARS-CoV-2 Replication. Mol Cell, 80(1):164-174.e4(2020) [pubmed]
Keyword List
ProteomeXchange project tag: Sars-Cov-2, Covid-19
submitter keyword: TMT, SARS-CoV-2, COVID-19, Infection, Phospho
Contact List
Christian Münch
contact affiliationInstitute of Biochemistry II, Faculty of Medicine, Goethe University, Frankfurt am Main, Germany Frankfurt Cancer Institute, Frankfurt am Main, Germany Cardio-Pulmonary Institute, Frankfurt am Main, Germany
contact emailch.muench@em.uni-frankfurt.de
lab head
Kevin Klann
contact affiliationUniversitätsklinikum Frankfurt am Main
contact emailklann@em.uni-frankfurt.de
dataset submitter
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