PXD018202-1
PXD018202 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | A time-resolved multi-omics atlas of oleaginous fungus M. alpina in response to nitrogen availability |
Description | One of the most extensively studied questions in oleaginous microorganism is how cells alter gene expression to deal with growth-limiting perturbation, and resource allocation was especially recognized to contribute to TAGs accumulation. However, the strategies of resource allocation are poorly understood. Here, we examined how metabolic alternations induced by nitrogen starvation drive the TAGs accumulation in M. alpina by time-course phenotypes, metabolomics, lipidomics, and proteomic analyses.Our study offers a panoramic view of resource allocation of M. alpina in response to nutrient stress and reports a set of intriguing relations between resource reallocation and TAGs accumulation. This system-level insight provides a rich resource to explore in-depth functional characterization and informs a nutrient stress manipulation strategy of combining strain development and process integration to achieve better lipid productivity. |
HostingRepository | iProX |
AnnounceDate | 2020-03-25 |
AnnouncementXML | Submission_2022-11-27_22:31:39.379.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Hengqian Lu |
SpeciesList | scientific name: Mortierella alpina ATCC 32222; NCBI TaxID: 685557; |
ModificationList | No PTMs are included in the dataset |
Instrument | Orbitrap Fusion Lumos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2020-03-25 19:34:17 | ID requested | |
⏵ 1 | 2022-11-27 22:31:55 | announced |
Publication List
Lu H, Chen H, Tang X, Yang Q, Zhang H, Chen YQ, Chen W, . Biotechnol Biofuels, 13():116(2020) [pubmed] |
Keyword List
submitter keyword: Resource allocation, Lipid biosynthesis, Nutrient stress, Oleaginous microorganism, Cell recycling |
Contact List
Haiqin Chen | |
---|---|
contact affiliation | Jiangnan University |
contact email | haiqinchen@jiangnan.edu.cn |
lab head | |
Hengqian Lu | |
contact affiliation | Jiangnan University |
contact email | hengqianlu@163.com |
dataset submitter |
Full Dataset Link List
iProX dataset URI |