PXD018202

PXD018202 is an original dataset announced via ProteomeXchange.

Title	A time-resolved multi-omics atlas of oleaginous fungus M. alpina in response to nitrogen availability
Description	One of the most extensively studied questions in oleaginous microorganism is how cells alter gene expression to deal with growth-limiting perturbation, and resource allocation was especially recognized to contribute to TAGs accumulation. However, the strategies of resource allocation are poorly understood. Here, we examined how metabolic alternations induced by nitrogen starvation drive the TAGs accumulation in M. alpina by time-course phenotypes, metabolomics, lipidomics, and proteomic analyses.Our study offers a panoramic view of resource allocation of M. alpina in response to nutrient stress and reports a set of intriguing relations between resource reallocation and TAGs accumulation. This system-level insight provides a rich resource to explore in-depth functional characterization and informs a nutrient stress manipulation strategy of combining strain development and process integration to achieve better lipid productivity.
HostingRepository	iProX
AnnounceDate	2020-03-25
AnnouncementXML	Submission_2022-11-27_22:31:39.379.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Hengqian Lu
SpeciesList	scientific name: Mortierella alpina ATCC 32222; NCBI TaxID: 685557;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2020-03-25 19:34:17	ID requested
⏵ 1	2022-11-27 22:31:55	announced

Lu H, Chen H, Tang X, Yang Q, Zhang H, Chen YQ, Chen W, . Biotechnol Biofuels, 13():116(2020) [pubmed]

submitter keyword: Resource allocation, Lipid biosynthesis, Nutrient stress, Oleaginous microorganism, Cell recycling

Haiqin Chen
contact affiliation	Jiangnan University
contact email	haiqinchen@jiangnan.edu.cn
lab head
Hengqian Lu
contact affiliation	Jiangnan University
contact email	hengqianlu@163.com
dataset submitter

iProX dataset URI