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PXD017256-1

PXD017256 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleAutism-linked Cullin3 germline haploinsufficiency impacts cytoskeletal dynamics and cortical neurogenesis through RhoA signaling
DescriptionE3-ubiquitin ligase Cullin3 (Cul3) is a high confidence risk gene for neurodevelopmental disorders including autism spectrum disorder (ASD) and developmental delay (DD). We generated Cul3-haploinsufficient mouse model to investigate brain anatomy, behavior, molecular, cellular, and circuit-level mechanisms dysregulated by Cul3 mutations. Spatiotemporal transcriptomic and proteomic profiling of the brain implicated neurogenesis and cytoskeletal defects as key drivers of Cul3 functional impact. Quantitative proteomic profiling was performed by Tandem Mass Tag (TMT) labeling and liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis with SPS-MS3 workflow.
HostingRepositoryMassIVE
AnnounceDate2021-03-16
AnnouncementXMLSubmission_2021-03-16_19:18:36.207.xml
DigitalObjectIdentifier
ReviewLevelNon peer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterNam-Kyung Yu
SpeciesList scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090;
ModificationListS-carboxamidomethyl-L-cysteine; unknown modification
InstrumentOrbitrap Fusion
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-01-22 11:52:34ID requested
12021-03-16 19:18:36announced
Publication List
no publication
Keyword List
submitter keyword: TMT, Cullin3, Autism, Mouse brain
Contact List
Lilia Iakoucheva
contact affiliationUCSD
contact emaillilyak@health.ucsd.edu
lab head
Nam-Kyung Yu
contact affiliationScripps Research
contact emailnamkyung@scripps.edu
dataset submitter
Full Dataset Link List
MassIVE dataset URI
Dataset FTP location
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