PXD017154-1

PXD017154 is an original dataset announced via ProteomeXchange.

Title	T-cell alloreactivity to HLA-DP is regulated by peptide repertoire divergence and HLA-DM mediated editing
Description	Analysis of the peptide repertoires eluted from different HLA-DP molecules expressed in HeLa cells co-expressing Invariant chain either with or without HLA-DM as components of the HLA class II processing machinery. Divergence of the immunopeptidomes and the impact of HLA-DM were investigated in relation to the capacity of HLA-DP molecules to elicit alloreactive T-cell responses.
HostingRepository	PRIDE
AnnounceDate	2022-11-21
AnnouncementXML	Submission_2022-11-21_08:47:09.260.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD017154
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	PietroCrivello
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	Oxidation; monohydroxylated residue
Instrument	Orbitrap Fusion Lumos; LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2020-01-16 07:41:59	ID requested
⏵ 1	2022-11-21 08:47:09	announced
2	2023-11-14 08:50:51	announced	2023-11-14: Updated project metadata.

curator keyword: Biological

submitter keyword: HLA class II, HLA-DM, immunopeptidome, HLA-DP, T-cell alloreactivity

KatharinaFleischhauer
contact affiliation	Institute for Experimental Cellular Therapy, University Hospital Essen, Essen, Germany
contact email	fleischhauer.katharina@uk-essen.de
lab head
PietroCrivello
contact affiliation	Institute for Experimental Cellular Therapy
contact email	pietro.crivello@uk-essen.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/11/PXD017154

PRIDE project URI

• PRIDE
  1. PXD017154
     1. Label: PRIDE project
     2. Name: T-cell alloreactivity to HLA-DP is regulated by peptide repertoire divergence and HLA-DM mediated editing