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PXD016995-1

PXD016995 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProteomic Analysis of Proteins Downstream of Autism-Associated Gene DIXDC1
DescriptionDix domain containing 1 (Dixdc1) is an important regulator of neuronal development including cortical neurogenesis, neuronal migration and synaptic connectivity, and sequence variants in the gene have been linked to autism spectrum disorders (ASD). Previous studies indicate that Dixdc1 controls neurogenesis through Wnt signaling, while its regulation of dendrite and synapse development requires Wnt and cytoskeletal signaling. However, the prediction of these signaling pathways is primarily based on the structure of Dixdc1. Given the role of Dixdc1 in neural development and brain disorders, we hypothesized that Dixdc1 may regulate additional signaling pathways in the brain. We performed proteomic analyses of Dixdc1 KO mouse cortices to reveal such alterations.
HostingRepositoryPRIDE
AnnounceDate2020-12-21
AnnouncementXMLSubmission_2020-12-21_03:54:59.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterYu Lu
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListTMT6plex-126 reporter+balance reagent acylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-01-07 07:06:28ID requested
12020-12-21 03:54:59announced
Publication List
Dataset with its publication pending
Keyword List
curator keyword: Biomedical
submitter keyword: autism spectrum disorder, DISDC1, mouse, brain
Contact List
Yu Lu
contact affiliationDepartment of Biochemistry and Biomedical Sciences McMaster University
contact emailyu.lu@mcmaster.ca
lab head
Yu Lu
contact affiliationMcMaster University
contact emailyu.lu@mcmaster.ca
dataset submitter
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Dataset FTP location
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PRIDE project URI
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