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PXD016855 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleCerebral organoids model neocortical development disrupted by 16p11.2 CNV in autism
DescriptionThe 16p11.2 is the most common copy number variant (CNV) associated with Autism Spectrum Disorder (ASD). We used patient-derived cerebral organoids to investigate neurodevelopmental pathways dysregulated by dosage changes of 16p11.2 CNV. To investigate molecular dysregulation in DEL and DUP organoids, we carried out RNA sequencing and Tandem Mass Tag mass spectrometry (TMT-MS) on 1-month and 3-month organoids from the same samples. In proteomic analyses, we quantified a total of 6126 proteins in 1-month and 5481 proteins in 3-month organoids, with 13 and 11 proteins from within 16p11.2 CNV, respectively. Transcriptomic and proteomic profiling of organoids identifies the key drivers of functional effect by 16p11.2 CNV during neocortical development.
ReviewLevelNon peer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterNam-Kyung Yu
SpeciesList scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606;
ModificationListS-carboxamidomethyl-L-cysteine; unknown modification
InstrumentOrbitrap Fusion
Dataset History
RevisionDatetimeStatusChangeLog Entry
02019-12-19 10:17:49ID requested
12021-08-02 20:58:54announced
Publication List
no publication
Keyword List
submitter keyword: TMT 10-plex, cerebral organoid, autism, 16p11.2 CNV
Contact List
Lilia Iakoucheva
contact affiliationUCSD
contact emaillilyak@health.ucsd.edu
lab head
Nam-Kyung Yu
contact affiliationScripps Research
contact emailnamkyung@scripps.edu
dataset submitter
Full Dataset Link List
MassIVE dataset URI
Dataset FTP location
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