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PXD016674 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleMulti-omics profiling of non-small cell lung cancer patient-derived xenografts reveals proteome and phosphoproteome remodeling associated with patient outcome
Description131 patient-derived xenograft models were generated for non-small cell lung carcinoma and were profiled at the genome, transcriptome and proteome level by analysis of gene copy number variation, whole exome sequencing, DNA methylation, transcriptome, proteome and phospho(Tyr)-proteome. At the proteome level, the human tumor and murine stroma were discernible. Tumor proteome profiling resolved the known major histological subtypes and revealed 3 proteome subtypes (proteotypes) among adenocarcinoma and 2 in squamous cell carcinoma that were associated with distinct protein-phosphotyrosine signatures and patient survival. Stromal proteomes were similar between histological subtypes, but two adenocarcinoma proteotypes had distinct stromal proteomes. Proteotypes comprise tumor and stromal signatures of targetable biological pathways suggesting that patient stratification by proteome profiling may be an actionable approach to precisely diagnose and treat cancer.
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterJiefei Tong
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListphosphorylated residue
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02019-12-10 01:33:19ID requested
12021-11-24 11:37:38announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Human, NSCLC, phosphorylation, tyrosine, proteome, PDX
Contact List
Jiefei Tong
contact affiliationHospital for Sick Children, Toronto, Ontario, Canada
contact emailjiefei.tong@sickkids.ca
lab head
Jiefei Tong
contact affiliationHospital for Sickkids
contact emailjiefei.tong@sickkids.ca
dataset submitter
Full Dataset Link List
Dataset FTP location
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