PXD016674-1

PXD016674 is an original dataset announced via ProteomeXchange.

Title	Multi-omics profiling of non-small cell lung cancer patient-derived xenografts reveals proteome and phosphoproteome remodeling associated with patient outcome
Description	131 patient-derived xenograft models were generated for non-small cell lung carcinoma and were profiled at the genome, transcriptome and proteome level by analysis of gene copy number variation, whole exome sequencing, DNA methylation, transcriptome, proteome and phospho(Tyr)-proteome. At the proteome level, the human tumor and murine stroma were discernible. Tumor proteome profiling resolved the known major histological subtypes and revealed 3 proteome subtypes (proteotypes) among adenocarcinoma and 2 in squamous cell carcinoma that were associated with distinct protein-phosphotyrosine signatures and patient survival. Stromal proteomes were similar between histological subtypes, but two adenocarcinoma proteotypes had distinct stromal proteomes. Proteotypes comprise tumor and stromal signatures of targetable biological pathways suggesting that patient stratification by proteome profiling may be an actionable approach to precisely diagnose and treat cancer.
HostingRepository	PRIDE
AnnounceDate	2021-11-24
AnnouncementXML	Submission_2021-11-24_11:37:37.824.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jiefei Tong
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2019-12-10 01:33:19	ID requested
⏵ 1	2021-11-24 11:37:38	announced

Dataset with its publication pending

submitter keyword: Human, NSCLC, phosphorylation, tyrosine, proteome, PDX

Jiefei Tong
contact affiliation	Hospital for Sick Children, Toronto, Ontario, Canada
contact email	jiefei.tong@sickkids.ca
lab head
Jiefei Tong
contact affiliation	Hospital for Sickkids
contact email	jiefei.tong@sickkids.ca
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD016674
     1. Label: PRIDE project
     2. Name: Multi-omics profiling of non-small cell lung cancer patient-derived xenografts reveals proteome and phosphoproteome remodeling associated with patient outcome