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PXD016425-1

PXD016425 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleLandscapes of post-translational modifications in Trypanosoma parasites
DescriptionProteins of all living cells undergo a myriad of posttranslational modifications (PTMs) that are critical to multifarious life processes. In this study, we describe the first comprehensive multiple PTM-omics atlas in parallel with quantitative proteome analyses of two representative species of trypanosomes, Trypanosoma brucei and T. evansi. Approximately 40,000 modified sites and 150 histone marks were identified in each species. Proteins involved in the redox system were mainly regulated in T. brucei, while proteins associated with motility were predominantly modified in T. evansi. The establishment of a database of multiple PTMs in the two parasites provides us with insight into the biological mechanisms that underpin life processes in trypanosomes with huge different life cycles.
HostingRepositoryPRIDE
AnnounceDate2020-06-30
AnnouncementXMLSubmission_2020-06-29_23:30:55.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterNaiwen Zhang
SpeciesList scientific name: Trypanosoma brucei brucei; NCBI TaxID: 5702;
ModificationListacetylated residue
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02019-11-25 02:11:40ID requested
12020-06-29 23:30:56announced
Publication List
Zhang N, Jiang N, Zhang K, Zheng L, Zhang D, Sang X, Feng Y, Chen R, Yang N, Wang X, Cheng Z, Suo X, Lun Z, Chen Q, Landscapes of Protein Posttranslational Modifications of African Trypanosoma Parasites. iScience, 23(5):101074(2020) [pubmed]
Keyword List
submitter keyword: Trypanosoma brucei
Trypanosoma evansi
post-translational modification
acetylation
crotonyltion
2-hydroxyisobutyrylation
malonylation
succinylation
ubiquitination
trimethylation
phosphorylation
N-glycosylation
O-GlcNAcylation
Contact List
Qijun Chen
contact affiliationShenyang Agricultural University
contact emailqijunchen759@syau.edu.cn
lab head
Naiwen Zhang
contact affiliationShenyang Agricultural University
contact emailnaiwenzhang@stu.syau.edu.cn
dataset submitter
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Dataset FTP location
PRIDE project URI
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