PXD016425-1

PXD016425 is an original dataset announced via ProteomeXchange.

Title	Landscapes of post-translational modifications in Trypanosoma parasites
Description	Proteins of all living cells undergo a myriad of posttranslational modifications (PTMs) that are critical to multifarious life processes. In this study, we describe the first comprehensive multiple PTM-omics atlas in parallel with quantitative proteome analyses of two representative species of trypanosomes, Trypanosoma brucei and T. evansi. Approximately 40,000 modified sites and 150 histone marks were identified in each species. Proteins involved in the redox system were mainly regulated in T. brucei, while proteins associated with motility were predominantly modified in T. evansi. The establishment of a database of multiple PTMs in the two parasites provides us with insight into the biological mechanisms that underpin life processes in trypanosomes with huge different life cycles.
HostingRepository	PRIDE
AnnounceDate	2020-06-30
AnnouncementXML	Submission_2020-06-29_23:30:55.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Naiwen Zhang
SpeciesList	scientific name: Trypanosoma brucei brucei; NCBI TaxID: 5702;
ModificationList	acetylated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2019-11-25 02:11:40	ID requested
⏵ 1	2020-06-29 23:30:56	announced

Zhang N, Jiang N, Zhang K, Zheng L, Zhang D, Sang X, Feng Y, Chen R, Yang N, Wang X, Cheng Z, Suo X, Lun Z, Chen Q, Landscapes of Protein Posttranslational Modifications of African Trypanosoma Parasites. iScience, 23(5):101074(2020) [pubmed]

submitter keyword: Trypanosoma brucei

Trypanosoma evansi

post-translational modification

acetylation

crotonyltion

2-hydroxyisobutyrylation

malonylation

succinylation

ubiquitination

trimethylation

phosphorylation

N-glycosylation

O-GlcNAcylation

Qijun Chen
contact affiliation	Shenyang Agricultural University
contact email	qijunchen759@syau.edu.cn
lab head
Naiwen Zhang
contact affiliation	Shenyang Agricultural University
contact email	naiwenzhang@stu.syau.edu.cn
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/06/PXD016425

PRIDE project URI

• PRIDE
  1. PXD016425
     1. Label: PRIDE project
     2. Name: Landscapes of post-translational modifications in Trypanosoma parasites