PXD015936

PXD015936 is an original dataset announced via ProteomeXchange.

Title	Quantitative phosphoproteomics analysis uncovers the regulatory networks of ZNF322A in lung cancer cells
Description	Cys2His2 (C2H2)-type zinc finger (ZNF) is one of the most common DNA-binding motif and plays a major role as transcription factors, which encoded by 2% of human genes. C2H2 type ZNFs are reported as proteins of great versatility, such as regulation of differentiation, development, metabolism, cell survival, apoptosis, and autophagy. To uncover ZNF322A-mediated functional network, we applied phosphopeptide enrichment and isobaric labeling strategies with MS-based proteomics, and identified 2754 phosphorylation sites on 976 phosphoproteins.
HostingRepository	PRIDE
AnnounceDate	2021-09-08
AnnouncementXML	Submission_2021-09-08_11:41:09.783.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Chantal Hoi Yin Cheung
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2019-10-21 04:08:09	ID requested
⏵ 1	2021-09-08 11:41:10	announced

Cheung CHY, Hsu CL, Lin TY, Chen WT, Wang YC, Huang HC, Juan HF, ZNF322A-mediated protein phosphorylation induces autophagosome formation through modulation of IRS1-AKT glucose uptake and HSP-elicited UPR in lung cancer. J Biomed Sci, 27(1):75(2020) [pubmed]

submitter keyword: Human lung cancer, ZNF322A, phosphoproteomics

Hsueh-Fen Juan, Ph.D.
contact affiliation	Department of Life Science, National Taiwan University
contact email	yukijuan@ntu.edu.tw
lab head
Chantal Hoi Yin Cheung
contact affiliation	national taiwan university
contact email	hycchantal@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/09/PXD015936

PRIDE project URI

• PRIDE
  1. PXD015936
     1. Label: PRIDE project
     2. Name: Quantitative phosphoproteomics analysis uncovers the regulatory networks of ZNF322A in lung cancer cells