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PXD015887 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleSubcellular quantitative proteomic analysis of herpes simplex virus type 1 infected HEK 293T cells
DescriptionHerpes simplex virus type-1 (HSV-1) is wide-spread dsDNA virus that establishes life-long latency and causes diverse severity of symptoms. In this study, HEK 293T cells with low Toll-like receptor (TLR) and Stimulator of interferon genes protein (STING) expression was infected with HSV-1 and subjected to quantitative proteomic analysis. By using a subcellular fractionation strategy and high-performance mass spectrometry, a total of 5,982 host proteins were quantified, of which 484 proteins were differentially regulated. Bioinformatics analysis indicated that multiple signaling pathways were involved in HSV-1 infection.
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterLeike Zhang
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListphosphorylated residue
InstrumentTripleTOF 5600
Dataset History
RevisionDatetimeStatusChangeLog Entry
02019-10-18 01:46:22ID requested
12019-12-02 02:55:40announced
Publication List
Wan W, Wang L, Chen X, Zhu S, Shang W, Xiao G, Zhang LK, A Subcellular Quantitative Proteomic Analysis of Herpes Simplex Virus Type 1-Infected HEK 293T Cells. Molecules, 24(23):(2019) [pubmed]
Keyword List
submitter keyword: Quantitative proteomics, Herpes simplex virus type 1, virus-host interaction, IFITM3, CHCHD2, TRIM27
Contact List
Liangjie Wang
contact affiliationHubei Key Laboratory of Puriļ¬cation and Application of Plant Anti-Cancer Active Ingredients, School of Chemistry and Life Sciences, Hubei University of Education, Wuhan, P. R. China
contact emailwangliangjie@hue.edu.cn
lab head
Leike Zhang
contact affiliationIOV
contact emailkebike1986@126.com
dataset submitter
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