PXD015887

PXD015887 is an original dataset announced via ProteomeXchange.

Title	Subcellular quantitative proteomic analysis of herpes simplex virus type 1 infected HEK 293T cells
Description	Herpes simplex virus type-1 (HSV-1) is wide-spread dsDNA virus that establishes life-long latency and causes diverse severity of symptoms. In this study, HEK 293T cells with low Toll-like receptor (TLR) and Stimulator of interferon genes protein (STING) expression was infected with HSV-1 and subjected to quantitative proteomic analysis. By using a subcellular fractionation strategy and high-performance mass spectrometry, a total of 5,982 host proteins were quantified, of which 484 proteins were differentially regulated. Bioinformatics analysis indicated that multiple signaling pathways were involved in HSV-1 infection.
HostingRepository	PRIDE
AnnounceDate	2019-12-02
AnnouncementXML	Submission_2019-12-02_02:55:39.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Leike Zhang
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue
Instrument	TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2019-10-18 01:46:22	ID requested
⏵ 1	2019-12-02 02:55:40	announced

Wan W, Wang L, Chen X, Zhu S, Shang W, Xiao G, Zhang LK, A Subcellular Quantitative Proteomic Analysis of Herpes Simplex Virus Type 1-Infected HEK 293T Cells. Molecules, 24(23):(2019) [pubmed]

submitter keyword: Quantitative proteomics, Herpes simplex virus type 1, virus-host interaction, IFITM3, CHCHD2, TRIM27

Liangjie Wang
contact affiliation	Hubei Key Laboratory of Purification and Application of Plant Anti-Cancer Active Ingredients, School of Chemistry and Life Sciences, Hubei University of Education, Wuhan, P. R. China
contact email	wangliangjie@hue.edu.cn
lab head
Leike Zhang
contact affiliation	IOV
contact email	kebike1986@126.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/12/PXD015887

PRIDE project URI

• PRIDE
  1. PXD015887
     1. Label: PRIDE project
     2. Name: Subcellular quantitative proteomic analysis of herpes simplex virus type 1 infected HEK 293T cells