PXD015684-1
PXD015684 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Decreased IgG core fucosylation, a player in antibody-dependent cell-mediated cytotoxicity, is associated with autoimmune thyroid diseases |
Description | Autoimmune thyroid diseases (AITD) are the most common group of autoimmune diseases, associated with lymphocyte infiltration and the production of thyroid autoantibodies, like thyroid peroxidase antibodies (TPOAb), in the thyroid gland. Immunoglobulins (Igs) and cell-surface receptors are glycoproteins with distinctive glycosylation patterns that play a structural role in maintaining and modulating their functions. We investigated associations of total circulating IgG and peripheral blood mononuclear cells (PBMCs) glycosylation with AITD and the influence of genetic background. The study revealed an inverse association of IgG core fucosylation with TPOAb and PBMCs antennary ??????????????????1,2 fucosylation with AITD, but no shared genetic variance between AITD and glycosylation. These data suggest that the decreased level of IgG core fucosylation is a risk factor for AITD that promotes antibody-dependent cell-mediated cytotoxicity (ADCC) associated with TPOAb levels |
HostingRepository | PRIDE |
AnnounceDate | 2020-02-14 |
AnnouncementXML | Submission_2020-02-14_04:21:07.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Marta Z??????????????????bczy??????????????????ska |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | monohydroxylated residue; iodoacetic acid derivatized residue |
Instrument | Orbitrap Fusion |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2019-10-02 06:51:43 | ID requested | |
⏵ 1 | 2020-02-14 04:21:09 | announced |
Publication List
Martin TC, Š, imurina M, Z, ą, bczy, ń, ska M, Martinic Kavur M, Rydlewska M, Pezer M, Koz, ł, owska K, Burri A, Vilaj M, Turek-Jabrocka R, Krnjaji, ć, -Tadijanovi, ć M, Trofimiuk-M, ü, ldner M, Ugrina I, Lity, ń, ska A, Hubalewska-Dydejczyk A, Trbojevic-Akmacic I, Lim EM, Walsh JP, Poche, ć E, Spector TD, Wilson SG, Lauc G, Decreased Immunoglobulin G Core Fucosylation, A Player in Antibody-dependent Cell-mediated Cytotoxicity, is Associated with Autoimmune Thyroid Diseases. Mol Cell Proteomics, 19(5):774-792(2020) [pubmed] |
Keyword List
submitter keyword: Human, PBMC, Hashimoto's thyroiditis |
Contact List
Ewa Poche?????????????????? | |
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contact affiliation | Dept. of Glycoconjugate Biochemistry Institute of Zoology and Biomedical Research Jagiellonian University |
contact email | ewa.pochec@uj.edu.pl |
lab head | |
Marta Z??????????????????bczy??????????????????ska | |
contact affiliation | Department of Glycoconjugate Biochemistry, Institute of Zoology and Biomedical Research, Jagiellonian University, Krak??????????????????w, |
contact email | marta.zabczynska@doctoral.uj.edu.pl |
dataset submitter |
Full Dataset Link List
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PRIDE project URI |
Repository Record List
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