PXD015684

PXD015684 is an original dataset announced via ProteomeXchange.

Title	Decreased IgG core fucosylation, a player in antibody-dependent cell-mediated cytotoxicity, is associated with autoimmune thyroid diseases
Description	Autoimmune thyroid diseases (AITD) are the most common group of autoimmune diseases, associated with lymphocyte infiltration and the production of thyroid autoantibodies, like thyroid peroxidase antibodies (TPOAb), in the thyroid gland. Immunoglobulins (Igs) and cell-surface receptors are glycoproteins with distinctive glycosylation patterns that play a structural role in maintaining and modulating their functions. We investigated associations of total circulating IgG and peripheral blood mononuclear cells (PBMCs) glycosylation with AITD and the influence of genetic background. The study revealed an inverse association of IgG core fucosylation with TPOAb and PBMCs antennary α1,2 fucosylation with AITD, but no shared genetic variance between AITD and glycosylation. These data suggest that the decreased level of IgG core fucosylation is a risk factor for AITD that promotes antibody-dependent cell-mediated cytotoxicity (ADCC) associated with TPOAb levels
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:11:40.020.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Marta Ząbczyńska
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetic acid derivatized residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2019-10-02 06:51:43	ID requested
1	2020-02-14 04:21:09	announced
⏵ 2	2024-10-22 04:11:40	announced	2024-10-22: Updated project metadata.

10.1074/mcp.ra119.001860;

Martin TC, Š, imurina M, Z, ą, bczy, ń, ska M, Martinic Kavur M, Rydlewska M, Pezer M, Koz, ł, owska K, Burri A, Vilaj M, Turek-Jabrocka R, Krnjaji, ć, -Tadijanovi, ć M, Trofimiuk-M, ü, ldner M, Ugrina I, Lity, ń, ska A, Hubalewska-Dydejczyk A, Trbojevic-Akmacic I, Lim EM, Walsh JP, Poche, ć E, Spector TD, Wilson SG, Lauc G, Decreased Immunoglobulin G Core Fucosylation, A Player in Antibody-dependent Cell-mediated Cytotoxicity, is Associated with Autoimmune Thyroid Diseases. Mol Cell Proteomics, 19(5):774-792(2020) [pubmed]

submitter keyword: Human, PBMC, Hashimoto's thyroiditis

Ewa Pocheć
contact affiliation	Dept. of Glycoconjugate Biochemistry Institute of Zoology and Biomedical Research Jagiellonian University
contact email	ewa.pochec@uj.edu.pl
lab head
Marta Ząbczyńska
contact affiliation	Department of Glycoconjugate Biochemistry, Institute of Zoology and Biomedical Research, Jagiellonian University, Kraków,
contact email	marta.zabczynska@doctoral.uj.edu.pl
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/02/PXD015684

PRIDE project URI

• PRIDE
  1. PXD015684
     1. Label: PRIDE project
     2. Name: Decreased IgG core fucosylation, a player in antibody-dependent cell-mediated cytotoxicity, is associated with autoimmune thyroid diseases