PXD014806 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Comparison of Protein Expression During Early Phases of Limb Regeneration Between Regeneration-permissive and Regeneration-deficient Axolotl |
Description | In this project, we studied the proteomic profiles of the early stages of blastema formation of neotenic and metamorphic axolotls after limb amputation by means of LC-MS/MS technology. We quantified a total of 714 proteins having an adjusted p < 0.01 with FC greater or equal to 2 between two conditions. Principal component analysis revealed a conspicuous clustering between neotenic and metamorphic samples at 7 days post-amputation. Different set of proteins was identified as differentially expressed at all of the time points (1, 4, and 7 days post-amputations against day0) for neotenic and metamorphic stages. Although functional enrichment analyses underline the presence of common pathways between regenerative and non-regenerative stages, cell proliferation and its regulation associated pathways, immune system related pathways and muscle tissue and ECM remodeling and degradation pathways were represented at different rate between both stages. |
HostingRepository | PRIDE |
AnnounceDate | 2019-11-25 |
AnnouncementXML | Submission_2020-01-14_07:32:34.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD014806 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Baris Suzek |
SpeciesList | scientific name: Ambystoma mexicanum; NCBI TaxID: 8296; |
ModificationList | Ammonia-loss; Deamidated; Dehydrated; Oxidation; Acetyl; Carbamidomethyl |
Instrument | SYNAPT G2-Si; ACQUITY UPLC |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2019-07-29 05:37:39 | ID requested | |
1 | 2019-11-25 07:20:26 | announced | |
⏵ 2 | 2020-01-14 07:32:35 | announced | 2020-01-14: Updated publication reference for PubMed record(s): 31767146. |
Publication List
Sibai M, Altunta, ş E, S, ü, zek BE, Ş, ahin B, Parlayan C, Ö, zt, ü, rk G, Baykal AT, Demircan T, Comparison of protein expression profile of limb regeneration between neotenic and metamorphic axolotl. Biochem Biophys Res Commun, 522(2):428-434(2020) [pubmed] |
Keyword List
submitter keyword: Proteomics |
Axolotl |
Limb regeneration |
Metamorphosis |
Gene expression profile |
Contact List
Turan Demircan |
contact affiliation | Regenerative and Restorative Medicine Research Center, REMER, Istanbul Medipol University, Istanbul, Turkey Department of Medical Biology, School of Medicine, Mugla Sitki Kocman University, Mugla, Turkey |
contact email | turandemircan@gmail.com |
lab head | |
Baris Suzek |
contact affiliation | Mugla Sitki Kocman University |
contact email | barissuzek@mu.edu.tr |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD014806
- Label: PRIDE project
- Name: Comparison of Protein Expression During Early Phases of Limb Regeneration Between Regeneration-permissive and Regeneration-deficient Axolotl