PXD014711 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Drug-tolerant cell-derived exosomes regulate proteasome inhibitor resistance pathways in MLL leukemias |
Description | The interplay between cancer cells and microenvironment can influence treatment response and plays a key role in the emergence of drug resistance. Rapidly acquired resistance prevents proteasome inhibitors (PIs) therapies from achieving stable and complete responses. Investigating the underlying mechanisms and developing effective strategies against PI resistance are highly desired in the clinic. Here we uncovered that PI resistance was reversible in MLL leukemia, which consistent with the finding that patients could regain sensitivity to PIs after a drug holiday. Exosomes derived from drug-tolerant cells could transmit PI resistance to sensitive cells via facilitating cell cycle arrest and stemness pathway in MLL leukemia cells. Furthermore, TieDIE algorithm integration analysis of transcriptome and proteome datasets identified candidate exosomal proteins, providing potential therapeutic targets for treating refractory MLL leukemia. Therefore, exosomal regulatory proteins may serve as a predictor and a potential therapeutic target for PI resistance, and inhibiting the secretion of exosomes is a promising strategy for restoring PI resistance in vivo, which provides a paradigm and may also be applied for the treatment of other cancers resulting from chemotherapy relapse. |
HostingRepository | PRIDE |
AnnounceDate | 2020-05-26 |
AnnouncementXML | Submission_2020-05-26_15:31:06.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Zhi Qiao |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | LTQ Orbitrap |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2019-07-23 05:49:45 | ID requested | |
⏵ 1 | 2020-05-26 15:31:07 | announced | |
Publication List
Ge M, Qiao Z, Kong Y, Lu H, Liu H, Exosomes mediate intercellular transfer of non-autonomous tolerance to proteasome inhibitors in mixed-lineage leukemia. Cancer Sci, 111(4):1279-1290(2020) [pubmed] |
Keyword List
submitter keyword: exosomes, drug tolerance, proteasome inhibitor, MLL leukemia |
Contact List
Han Liu |
contact affiliation | State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital, School of Medicine and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University |
contact email | liuhan68@sjtu.edu.cn |
lab head | |
Zhi Qiao |
contact affiliation | Shanghai Jiao Tong University |
contact email | zhiqiao@sjtu.edu.cn |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD014711
- Label: PRIDE project
- Name: Drug-tolerant cell-derived exosomes regulate proteasome inhibitor resistance pathways in MLL leukemias