PXD013821 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Impairment of autophagic flux by combined EGFR and ROCK inhibition leads to triple-negative breast cancer cell death |
Description | Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with very limited therapeutic options. We have recently shown that the combined inhibition of EGFR and ROCK in TNBC cells results in cell cycle arrest and ultimately cell death. However, the underlying mechanisms by which co-inhibition of EGFR and ROCK induces cell death remain unclear. To investigate the synergistic effect of the combination treatment on TNBC cells, in the present study we applied a mass spectrometry-based proteomic approach to identify proteins altered upon single and combination treatments. |
HostingRepository | PRIDE |
AnnounceDate | 2019-12-04 |
AnnouncementXML | Submission_2019-12-04_08:22:17.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Stamatia Rontogianni |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | phosphorylated residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2019-05-13 06:42:17 | ID requested | |
⏵ 1 | 2019-12-04 08:22:24 | announced | |
Publication List
Rontogianni S, Iskit S, van Doorn S, Peeper DS, Altelaar M, Combined EGFR and ROCK Inhibition in Triple-negative Breast Cancer Leads to Cell Death Via Impaired Autophagic Flux. Mol Cell Proteomics, 19(2):261-277(2020) [pubmed] |
Keyword List
submitter keyword: triple-negative breast cancer, targeted therapy, proteomics, label-free, EGFR, ROCK, autophagy |
Contact List
A. F. Maarten Altelaar |
contact affiliation | Biomolecular Mass Spectrometry and Proteomics Group, Utrecht University |
contact email | m.altelaar@uu.nl |
lab head | |
Stamatia Rontogianni |
contact affiliation | Utrecht University |
contact email | s.rontogianni@uu.nl |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/12/PXD013821 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD013821
- Label: PRIDE project
- Name: Impairment of autophagic flux by combined EGFR and ROCK inhibition leads to triple-negative breast cancer cell death