PXD013821

PXD013821 is an original dataset announced via ProteomeXchange.

Title	Impairment of autophagic flux by combined EGFR and ROCK inhibition leads to triple-negative breast cancer cell death
Description	Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with very limited therapeutic options. We have recently shown that the combined inhibition of EGFR and ROCK in TNBC cells results in cell cycle arrest and ultimately cell death. However, the underlying mechanisms by which co-inhibition of EGFR and ROCK induces cell death remain unclear. To investigate the synergistic effect of the combination treatment on TNBC cells, in the present study we applied a mass spectrometry-based proteomic approach to identify proteins altered upon single and combination treatments.
HostingRepository	PRIDE
AnnounceDate	2019-12-04
AnnouncementXML	Submission_2019-12-04_08:22:17.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Stamatia Rontogianni
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2019-05-13 06:42:17	ID requested
⏵ 1	2019-12-04 08:22:24	announced

Rontogianni S, Iskit S, van Doorn S, Peeper DS, Altelaar M, Combined EGFR and ROCK Inhibition in Triple-negative Breast Cancer Leads to Cell Death Via Impaired Autophagic Flux. Mol Cell Proteomics, 19(2):261-277(2020) [pubmed]

submitter keyword: triple-negative breast cancer, targeted therapy, proteomics, label-free, EGFR, ROCK, autophagy

A. F. Maarten Altelaar
contact affiliation	Biomolecular Mass Spectrometry and Proteomics Group, Utrecht University
contact email	m.altelaar@uu.nl
lab head
Stamatia Rontogianni
contact affiliation	Utrecht University
contact email	s.rontogianni@uu.nl
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD013821
     1. Label: PRIDE project
     2. Name: Impairment of autophagic flux by combined EGFR and ROCK inhibition leads to triple-negative breast cancer cell death