PXD013708 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Changes in the oligodendrocyte cell progenitor cell proteome with ageing |
Description | Following CNS demyelination, adult oligodendrocyte progenitor cells (OPCs) can differentiate into new myelin-forming oligodendrocytes in a regenerative process called remyelination. While remyelination is very efficient in young adults, its efficiency declines progressively with ageing. Here we performed proteomic analysis on OPCs isolated acutely from the brains of neonate, young and aged female rats. Approximately 60% of the proteins are expressed at different levels in OPCs from neonates compared to their adult counterparts. The amount of myelin-associated and cell adhesion proteins are increased with age, while cholesterol-biosynthesis, transcription factors and cell cycle proteins decreased. Our experiments provide the first ageing OPC rodent proteome, revealing the distinct features of neonatal and adult OPCs, and providing new insights into why remyelination efficiency declines with ageing and potential roles for aged OPCs in other neurodegenerative diseases. |
HostingRepository | PRIDE |
AnnounceDate | 2020-05-22 |
AnnouncementXML | Submission_2020-05-22_05:43:04.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Rayner Queiroz |
SpeciesList | scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116; |
ModificationList | deaminated residue; iodoacetamide derivatized residue |
Instrument | Orbitrap Fusion |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2019-05-03 04:47:41 | ID requested | |
⏵ 1 | 2020-05-22 05:43:05 | announced | |
Publication List
de la Fuente AG, Queiroz RML, Ghosh T, McMurran CE, Cubillos JF, Bergles DE, Fitzgerald DC, Jones CA, Lilley KS, Glover CP, Franklin RJM, Changes in the Oligodendrocyte Progenitor Cell Proteome with Ageing. Mol Cell Proteomics, 19(8):1281-1302(2020) [pubmed] |
Keyword List
submitter keyword: OPC ageing, proteomics, primary cells |
Contact List
Prof. Robin J Franklin |
contact affiliation | Wellcome-MRC Cambridge Stem Cell Institute Clifford Allbutt Building, Cambridge Biomedical Campus |
contact email | rjf1000@cam.ac.uk |
lab head | |
Rayner Queiroz |
contact affiliation | University of Cambridge |
contact email | rq214@cam.ac.uk |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD013708
- Label: PRIDE project
- Name: Changes in the oligodendrocyte cell progenitor cell proteome with ageing