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PXD013639-1

PXD013639 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleAging-related inflammation driven by cellular senescence enhances NAD consumption via activation of CD38+ macrophages
DescriptionDecline in tissue NAD levels during aging has been linked to aging-associated diseases, such as age-related metabolic disease, physical decline, and Alzheimers disease. However, the mechanism for aging-associated NAD decline remains unclear. Here we report that pro-inflammatory M1 macrophages, but not naive or M2 macrophages, highly express the NAD consuming enzyme CD38 and have enhanced CD38-dependent NADase activity. Furthermore, we show that aging is associated with enhanced inflammation due to increased senescent cells, and the accumulation of CD38 positive M1 macrophages in visceral white adipose tissue. We also find that inflammatory cytokines found in the supernatant from senescent cells (Senescence associated secretory proteins, SASP) induces macrophages to proliferate and express CD38. As senescent cells progressively accumulate in adipose tissue during aging, these results highlight a new causal link between visceral tissue senescence and tissue NAD decline during aging and may present a novel therapeutic opportunity to maintain NAD levels during aging.
HostingRepositoryMassIVE
AnnounceDate2019-04-25
AnnouncementXMLSubmission_2019-04-25_13:51:42.xml
DigitalObjectIdentifier
ReviewLevelNon peer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterNate
SpeciesList scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090;
ModificationListCarbamidomethyl; Oxidation
InstrumentTripleTOF 6600; TripleTOF 5600
Dataset History
RevisionDatetimeStatusChangeLog Entry
02019-04-25 13:35:13ID requested
12019-04-25 13:51:43announced
Publication List
no publication
Keyword List
submitter keyword: aging, cd38, macrophages, NAD, senescence, secretome
Contact List
Birgit Schilling
contact affiliationBuck Institute for Research on Aging
contact emailbschilling@buckinstitute.org
lab head
Nate
contact affiliationThe Buck Institute for Research on Aging
contact emailnbasisty@buckinstitute.org
dataset submitter
Full Dataset Link List
MassIVE dataset URI
Dataset FTP location
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