PXD013639
PXD013639 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Aging-related inflammation driven by cellular senescence enhances NAD consumption via activation of CD38+ macrophages |
| Description | Decline in tissue NAD levels during aging has been linked to aging-associated diseases, such as age-related metabolic disease, physical decline, and Alzheimers disease. However, the mechanism for aging-associated NAD decline remains unclear. Here we report that pro-inflammatory M1 macrophages, but not naive or M2 macrophages, highly express the NAD consuming enzyme CD38 and have enhanced CD38-dependent NADase activity. Furthermore, we show that aging is associated with enhanced inflammation due to increased senescent cells, and the accumulation of CD38 positive M1 macrophages in visceral white adipose tissue. We also find that inflammatory cytokines found in the supernatant from senescent cells (Senescence associated secretory proteins, SASP) induces macrophages to proliferate and express CD38. As senescent cells progressively accumulate in adipose tissue during aging, these results highlight a new causal link between visceral tissue senescence and tissue NAD decline during aging and may present a novel therapeutic opportunity to maintain NAD levels during aging. |
| HostingRepository | MassIVE |
| AnnounceDate | 2019-04-25 |
| AnnouncementXML | Submission_2019-04-25_13:51:42.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Nate |
| SpeciesList | scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090; |
| ModificationList | Carbamidomethyl; Oxidation |
| Instrument | TripleTOF 6600; TripleTOF 5600 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2019-04-25 13:35:13 | ID requested | |
| ⏵ 1 | 2019-04-25 13:51:43 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: aging, cd38, macrophages, NAD, senescence, secretome |
Contact List
| Birgit Schilling | |
|---|---|
| contact affiliation | Buck Institute for Research on Aging |
| contact email | bschilling@buckinstitute.org |
| lab head | |
| Nate | |
| contact affiliation | The Buck Institute for Research on Aging |
| contact email | nbasisty@buckinstitute.org |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000083726 |
to receive all new ProteomeXchange dataset release announcements!
