<<< Full experiment listing

PXD013442-1

PXD013442 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProteomic analysis of intracranial aneurysm
DescriptionIntracranial aneurysm (IA) is a pathological dilation of the cerebral artery which has a potential to rupture leading to sub arachnoid haemorrhage (SAH). One third of the patients with aneurysmal SAH (aSAH) develop symptomatic narrowing of the blood vessels called cerebral vasospasm. The outcomes in the above clinical scenarios are variable and devastating. The study was designed to decipher the molecular mechanisms underlying the pathophysiology of intracranial aneurysm formation, its rupture and subsequent development of vasospasm at the proteomic level. The study was done in two phases – discovery phase and validation phase. We performed iTRAQ-based quantitative proteomic analysis of brain vessel tissue and serum samples in three subgroups of patients with IA and compared them with those of control group (subjects with no cerebrovascular disorder) during the discovery phase. In validation phase, dysregulated proteins of biological significance i.e. ORM1 as a biomarker for unruptured aneurysm and MMP9 as a biomarker for cerebral vasospasm were validated in larger cohort of patients.
HostingRepositoryPRIDE
AnnounceDate2022-09-07
AnnouncementXMLSubmission_2022-09-07_04:15:39.720.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterHemant Bhagat
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListiTRAQ4plex-116 reporter+balance reagent acylated residue; monohydroxylated residue; iodoacetamide derivatized residue
InstrumentLTQ Orbitrap
Dataset History
RevisionDatetimeStatusChangeLog Entry
02019-04-10 03:52:47ID requested
12022-09-07 04:15:43announced
Publication List
Sharma T, Datta KK, Kumar M, Dey G, Khan AA, Mangalaparthi KK, Saharan P, Chinnapparaj S, Aggarwal A, Singla N, Ghosh S, Rawat A, Dhandapani S, Salunke P, Chhabra R, Singh D, Takkar A, Gupta SK, Prasad TSK, Gowda H, Mukherjee KK, Pandey A, Bhagat H, Intracranial Aneurysm Biomarker Candidates Identified by a Proteome-Wide Study. OMICS, 24(8):483-492(2020) [pubmed]
Keyword List
submitter keyword: vasospasm, iTRAQ, subarachnoid haemorrhage
Contact List
Hemant Bhagat
contact affiliationDepartment of Anaesthesia and Intensive Care, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, India.
contact emailhembhagat@rediffmail.com
lab head
Hemant Bhagat
contact affiliationPost Graduate Institute of Medical Education and Research (PGIMER), Chandigarh
contact emailhembhagat@rediffmail.com
dataset submitter
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/09/PXD013442
PRIDE project URI
Repository Record List
[ + ]