PXD013442

PXD013442 is an original dataset announced via ProteomeXchange.

Title	Proteomic analysis of intracranial aneurysm
Description	Intracranial aneurysm (IA) is a pathological dilation of the cerebral artery which has a potential to rupture leading to sub arachnoid haemorrhage (SAH). One third of the patients with aneurysmal SAH (aSAH) develop symptomatic narrowing of the blood vessels called cerebral vasospasm. The outcomes in the above clinical scenarios are variable and devastating. The study was designed to decipher the molecular mechanisms underlying the pathophysiology of intracranial aneurysm formation, its rupture and subsequent development of vasospasm at the proteomic level. The study was done in two phases – discovery phase and validation phase. We performed iTRAQ-based quantitative proteomic analysis of brain vessel tissue and serum samples in three subgroups of patients with IA and compared them with those of control group (subjects with no cerebrovascular disorder) during the discovery phase. In validation phase, dysregulated proteins of biological significance i.e. ORM1 as a biomarker for unruptured aneurysm and MMP9 as a biomarker for cerebral vasospasm were validated in larger cohort of patients.
HostingRepository	PRIDE
AnnounceDate	2022-09-07
AnnouncementXML	Submission_2022-09-07_04:15:39.720.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Hemant Bhagat
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iTRAQ4plex-116 reporter+balance reagent acylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap

Revision	Datetime	Status	ChangeLog Entry
0	2019-04-10 03:52:47	ID requested
⏵ 1	2022-09-07 04:15:43	announced

Sharma T, Datta KK, Kumar M, Dey G, Khan AA, Mangalaparthi KK, Saharan P, Chinnapparaj S, Aggarwal A, Singla N, Ghosh S, Rawat A, Dhandapani S, Salunke P, Chhabra R, Singh D, Takkar A, Gupta SK, Prasad TSK, Gowda H, Mukherjee KK, Pandey A, Bhagat H, Intracranial Aneurysm Biomarker Candidates Identified by a Proteome-Wide Study. OMICS, 24(8):483-492(2020) [pubmed]

submitter keyword: vasospasm, iTRAQ, subarachnoid haemorrhage

Hemant Bhagat
contact affiliation	Department of Anaesthesia and Intensive Care, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, India.
contact email	hembhagat@rediffmail.com
lab head
Hemant Bhagat
contact affiliation	Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh
contact email	hembhagat@rediffmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/09/PXD013442

PRIDE project URI

• PRIDE
  1. PXD013442
     1. Label: PRIDE project
     2. Name: Proteomic analysis of intracranial aneurysm