PXD013178-1

PXD013178 is an original dataset announced via ProteomeXchange.

Title	Reconstruction, refinement and validation of a Streptomyces coelicolor consensus genome scale metabolic model
Description	The rapid rise in antibiotic-resistance of microbial pathogens has brought the attention to new, heterologous approaches to better exploit the vast repertoire of biosynthetic gene clusters in Actinobacteria genomes and the large number of potentially novel bioactive compounds encoded in these. To enable and optimize production of these compounds, a better understanding of -among others- the interplay between primary and secondary metabolism in the selected suitable heterologous production hosts is needed, in our case the model Streptomycete Streptomyces coelicolor. In this study, a genome-scale metabolic model is reconstructed based on several previous metabolic models and refined by including experimental data, in particular proteome data. This new consensus model provides not only a valuable and more accurate mathematical representation to predict steady-state flux distributions in this strain, but also provides a new framework for interpretation and integration of different 'omics' data by the Streptomyces research community for improved strain-specific systems-scale knowledge to be used in targeted strain development, e.g. for efficient new antibiotics production.
HostingRepository	PRIDE
AnnounceDate	2020-09-10
AnnouncementXML	Submission_2020-09-09_23:14:36.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD013178
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Chao DU
SpeciesList	scientific name: Streptomyces coelicolor A3(2); NCBI TaxID: 100226;
ModificationList	Oxidation; Acetyl; Carbamidomethyl
Instrument	Synapt MS

Revision	Datetime	Status	ChangeLog Entry
0	2019-03-21 04:49:11	ID requested
⏵ 1	2020-09-09 23:14:37	announced

Dataset with its publication pending

submitter keyword: Streptomyces coelicolor, metabolic model, ScoGEM

Gilles van Wezel
contact affiliation	Institute of Biology Leiden, Leiden University
contact email	g.wezel@biology.leidenuniv.nl
lab head
Chao DU
contact affiliation	Leiden University
contact email	c.du@biology.leidenuniv.nl
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD013178
     1. Label: PRIDE project
     2. Name: Reconstruction, refinement and validation of a Streptomyces coelicolor consensus genome scale metabolic model