PXD013178 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Reconstruction, refinement and validation of a Streptomyces coelicolor consensus genome scale metabolic model |
Description | The rapid rise in antibiotic-resistance of microbial pathogens has brought the attention to new, heterologous approaches to better exploit the vast repertoire of biosynthetic gene clusters in Actinobacteria genomes and the large number of potentially novel bioactive compounds encoded in these. To enable and optimize production of these compounds, a better understanding of -among others- the interplay between primary and secondary metabolism in the selected suitable heterologous production hosts is needed, in our case the model Streptomycete Streptomyces coelicolor. In this study, a genome-scale metabolic model is reconstructed based on several previous metabolic models and refined by including experimental data, in particular proteome data. This new consensus model provides not only a valuable and more accurate mathematical representation to predict steady-state flux distributions in this strain, but also provides a new framework for interpretation and integration of different 'omics' data by the Streptomyces research community for improved strain-specific systems-scale knowledge to be used in targeted strain development, e.g. for efficient new antibiotics production. |
HostingRepository | PRIDE |
AnnounceDate | 2020-09-10 |
AnnouncementXML | Submission_2020-09-09_23:14:36.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD013178 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Chao DU |
SpeciesList | scientific name: Streptomyces coelicolor A3(2); NCBI TaxID: 100226; |
ModificationList | Oxidation; Acetyl; Carbamidomethyl |
Instrument | Synapt MS |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2019-03-21 04:49:11 | ID requested | |
⏵ 1 | 2020-09-09 23:14:37 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Streptomyces coelicolor, metabolic model, ScoGEM |
Contact List
Gilles van Wezel |
contact affiliation | Institute of Biology Leiden, Leiden University |
contact email | g.wezel@biology.leidenuniv.nl |
lab head | |
Chao DU |
contact affiliation | Leiden University |
contact email | c.du@biology.leidenuniv.nl |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD013178
- Label: PRIDE project
- Name: Reconstruction, refinement and validation of a Streptomyces coelicolor consensus genome scale metabolic model