PXD013030-1

PXD013030 is an original dataset announced via ProteomeXchange.

Title	Resistance Strategies Differ Against Specialist and Generalist Cyanophages
Description	Long-term coexistence between cyanobacteria and their lytic viruses (cyanophages) in the oceans is thought to be due to the presence of sensitive cells in which cyanophages reproduce, ultimately killing the cell, while other cyanobacteria survive due to resistance to infection. Here we investigated resistance strategies in naturally resistant cyanobacteria and compared strategies against generalist and specialist cyanophages. Resistance was extracellular in most interactions against specialist cyanophages, preventing entry into the cell. In contrast, resistance was intracellular in practically all interactions against generalist cyanophages. Intriguingly, the stage of intracellular arrest was interaction-specific, halting at various stages of the infection cycle. These findings unveil a heavy cost of promiscuous entry of generalist phages into non-host cells that is rarely paid by specialists, potential unknown mechanisms of intracellular resistance and that the range for viral-mediated horizontal gene transfer extends much beyond just hosts.
HostingRepository	PRIDE
AnnounceDate	2019-08-12
AnnouncementXML	Submission_2019-08-12_05:19:32.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Tamar Ziv
SpeciesList	scientific name: Escherichia coli; NCBI TaxID: 562;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2019-03-11 02:09:36	ID requested
⏵ 1	2019-08-12 05:19:33	announced

Zborowsky S, Lindell D, Resistance in marine cyanobacteria differs against specialist and generalist cyanophages. Proc Natl Acad Sci U S A, 116(34):16899-16908(2019) [pubmed]

curator keyword: Biomedical

submitter keyword: Cyanobacterial, resistance, cyanophages

Debbie Lindell
contact affiliation	Faculty of Biology, Technion – Israel Institute of Technology, Haifa 3200003, Israel
contact email	dlindell@technion.ac.il
lab head
Tamar Ziv
contact affiliation	Technion
contact email	tamarz@tx.technion.ac.il
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/08/PXD013030

PRIDE project URI

• PRIDE
  1. PXD013030
     1. Label: PRIDE project
     2. Name: Resistance Strategies Differ Against Specialist and Generalist Cyanophages