PXD012681-2

PXD012681 is an original dataset announced via ProteomeXchange.

Title	Semi-quantitative proteomics enables mapping of global neutrophil dynamics following influenza virus infection
Description	Lung neutrophils are causally associated with IAV-induced disease severity. Less is known about the repertoire of lethal IAV-associated neutrophil proteins or about how global changes in different neutrophil compartments are coordinated following lethal IAV infection. Here, we use semi-quantitative proteomics to characterize dynamic alterations in BM, blood and lung neutrophils at homeostasis or following a lethal IAV infection, with a secondary aim of identifying lung neutrophil-derived proteins which are selectively induced following IAV infection. Our findings identify bone marrow neutrophil maturation as the key site of anti-viral activity induction, with further upregulation or release of both anti-viral and antimicrobial effectors occurring following lung tissue infiltration.
HostingRepository	PRIDE
AnnounceDate	2019-05-29
AnnouncementXML	Submission_2019-07-18_00:55:31.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Chuanxin Liu
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	acetylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2019-02-12 08:02:04	ID requested
1	2019-05-29 05:31:51	announced
⏵ 2	2019-07-18 00:55:32	announced	Updated publication reference for PubMed record(s): 31308090.

Liu C, Oveissi S, Downs R, Kirby J, Nedeva C, Puthalakath H, Faou P, Duan M, Chen W, Semiquantitative Proteomics Enables Mapping of Murine Neutrophil Dynamics following Lethal Influenza Virus Infection. J Immunol, 203(4):1064-1075(2019) [pubmed]

curator keyword: Biomedical

submitter keyword: Mouse, Influenza, Neutrophil, LC-MS/MS

Weisan Chen
contact affiliation	Head, T cell Lab La Trobe Institute for Molecular Science, La Trobe University 1 Kingsbury Drive, Bundoora, Vic 3086 Australia
contact email	weisan.chen@latrobe.edu.au
lab head
Chuanxin Liu
contact affiliation	La Trobe University
contact email	18356364@students.latrobe.edu.au
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/05/PXD012681

PRIDE project URI

• PRIDE
  1. PXD012681
     1. Label: PRIDE project
     2. Name: Semi-quantitative proteomics enables mapping of global neutrophil dynamics following influenza virus infection