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PXD012681 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleSemi-quantitative proteomics enables mapping of global neutrophil dynamics following influenza virus infection
DescriptionLung neutrophils are causally associated with IAV-induced disease severity. Less is known about the repertoire of lethal IAV-associated neutrophil proteins or about how global changes in different neutrophil compartments are coordinated following lethal IAV infection. Here, we use semi-quantitative proteomics to characterize dynamic alterations in BM, blood and lung neutrophils at homeostasis or following a lethal IAV infection, with a secondary aim of identifying lung neutrophil-derived proteins which are selectively induced following IAV infection. Our findings identify bone marrow neutrophil maturation as the key site of anti-viral activity induction, with further upregulation or release of both anti-viral and antimicrobial effectors occurring following lung tissue infiltration.
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterChuanxin Liu
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListacetylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02019-02-12 08:02:04ID requested
12019-05-29 05:31:51announced
22019-07-18 00:55:32announcedUpdated publication reference for PubMed record(s): 31308090.
Publication List
Liu C, Oveissi S, Downs R, Kirby J, Nedeva C, Puthalakath H, Faou P, Duan M, Chen W, Semiquantitative Proteomics Enables Mapping of Murine Neutrophil Dynamics following Lethal Influenza Virus Infection. J Immunol, 203(4):1064-1075(2019) [pubmed]
Keyword List
curator keyword: Biomedical
submitter keyword: Mouse, Influenza, Neutrophil, LC-MS/MS
Contact List
Weisan Chen
contact affiliationHead, T cell Lab La Trobe Institute for Molecular Science, La Trobe University 1 Kingsbury Drive, Bundoora, Vic 3086 Australia
contact emailweisan.chen@latrobe.edu.au
lab head
Chuanxin Liu
contact affiliationLa Trobe University
contact email18356364@students.latrobe.edu.au
dataset submitter
Full Dataset Link List
Dataset FTP location
PRIDE project URI
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