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PXD012681

DataSet Summary

  • HostingRepository: PRIDE
  • AnnounceDate: 2019-05-29
  • AnnouncementXML: Submission_2019-07-18_00:55:31.xml
  • DigitalObjectIdentifier:
  • ReviewLevel: Peer-reviewed dataset
  • DatasetOrigin: Original data
  • RepositorySupport: Unsupported dataset by repository
  • PrimarySubmitter: Chuanxin Liu
  • Title: Semi-quantitative proteomics enables mapping of global neutrophil dynamics following influenza virus infection
  • Description: Lung neutrophils are causally associated with IAV-induced disease severity. Less is known about the repertoire of lethal IAV-associated neutrophil proteins or about how global changes in different neutrophil compartments are coordinated following lethal IAV infection. Here, we use semi-quantitative proteomics to characterize dynamic alterations in BM, blood and lung neutrophils at homeostasis or following a lethal IAV infection, with a secondary aim of identifying lung neutrophil-derived proteins which are selectively induced following IAV infection. Our findings identify bone marrow neutrophil maturation as the key site of anti-viral activity induction, with further upregulation or release of both anti-viral and antimicrobial effectors occurring following lung tissue infiltration.
  • SpeciesList: scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
  • ModificationList: acetylated residue; iodoacetamide derivatized residue
  • Instrument: Q Exactive

Dataset History

VersionDatetimeStatusChangeLog Entry
02019-02-12 08:02:04ID requested
12019-05-29 05:31:51announced
22019-07-18 00:55:32announcedUpdated publication reference for PubMed record(s): 31308090.

Publication List

  1. Liu C, Oveissi S, Downs R, Kirby J, Nedeva C, Puthalakath H, Faou P, Duan M, Chen W, Semiquantitative Proteomics Enables Mapping of Murine Neutrophil Dynamics following Lethal Influenza Virus Infection. J Immunol, 203(4):1064-1075(2019) [pubmed]

Keyword List

  1. curator keyword: Biomedical
  2. submitter keyword: Mouse, Influenza, Neutrophil, LC-MS/MS

Contact List

    Weisan Chen
    • contact affiliation: Head, T cell Lab La Trobe Institute for Molecular Science, La Trobe University 1 Kingsbury Drive, Bundoora, Vic 3086 Australia
    • contact email: weisan.chen@latrobe.edu.au
    • lab head:
    Chuanxin Liu
    • contact affiliation: La Trobe University
    • contact email: 18356364@students.latrobe.edu.au
    • dataset submitter:

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