PXD012087-1

PXD012087 is an original dataset announced via ProteomeXchange.

Title	Kinome profiling of Non-Hodgkin Lymphoma identifies Tyro3 as a therapeutic target in PEL
Description	Non-Hodgkin lymphomas (NHL) make up the majority of lymphoma diagnoses and represent a very diverse set of malignancies. We sought to identify kinases uniquely upregulated in different NHL subtypes. Using Multiplexed Inhibitor Bead-mass spectrometry (MIB/MS), we found Tyro3 was uniquely upregulated and important for cell survival in primary effusion lymphoma (PEL), which is a viral lymphoma infected with Kaposi’s sarcoma-associated herpesvirus (KSHV).
HostingRepository	PRIDE
AnnounceDate	2019-07-11
AnnouncementXML	Submission_2019-07-11_01:13:18.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jason Wong
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue; acetylated residue; monohydroxylated residue; deamidated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2018-12-17 07:14:13	ID requested
⏵ 1	2019-07-11 01:13:19	announced
2	2019-08-01 04:45:41	announced	Updated publication reference for PubMed record(s): 31346082.

Dataset with its publication pending

submitter keyword: Kinome profiling, Non-Hodgkin lymphoma, primary effusion lymphoma, Tyro3

Blossom Andrea Damania
contact affiliation	Department of Microbiology and Immunology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, USA.
contact email	damania@med.unc.edu
lab head
Jason Wong
contact affiliation	University of North Carolina at Chapel Hill
contact email	wongjp@email.unc.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/07/PXD012087

PRIDE project URI

• PRIDE
  1. PXD012087
     1. Label: PRIDE project
     2. Name: Kinome profiling of Non-Hodgkin Lymphoma identifies Tyro3 as a therapeutic target in PEL