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PXD012087 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleKinome profiling of Non-Hodgkin Lymphoma identifies Tyro3 as a therapeutic target in PEL
DescriptionNon-Hodgkin lymphomas (NHL) make up the majority of lymphoma diagnoses and represent a very diverse set of malignancies. We sought to identify kinases uniquely upregulated in different NHL subtypes. Using Multiplexed Inhibitor Bead-mass spectrometry (MIB/MS), we found Tyro3 was uniquely upregulated and important for cell survival in primary effusion lymphoma (PEL), which is a viral lymphoma infected with Kaposi’s sarcoma-associated herpesvirus (KSHV).
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterJason Wong
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListphosphorylated residue; acetylated residue; monohydroxylated residue; deamidated residue
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02018-12-17 07:14:13ID requested
12019-07-11 01:13:19announced
22019-08-01 04:45:41announcedUpdated publication reference for PubMed record(s): 31346082.
Publication List
Wong JP, Stuhlmiller TJ, Giffin LC, Lin C, Bigi R, Zhao J, Zhang W, Bravo Cruz AG, Park SI, Earp HS, Dittmer DP, Frye SV, Wang X, Johnson GL, Damania B, Kinome profiling of non-Hodgkin lymphoma identifies Tyro3 as a therapeutic target in primary effusion lymphoma. Proc Natl Acad Sci U S A, 116(33):16541-16550(2019) [pubmed]
Keyword List
submitter keyword: Kinome profiling, Non-Hodgkin lymphoma, primary effusion lymphoma, Tyro3
Contact List
Blossom Andrea Damania
contact affiliationDepartment of Microbiology and Immunology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, USA.
contact emaildamania@med.unc.edu
lab head
Jason Wong
contact affiliationUniversity of North Carolina at Chapel Hill
contact emailwongjp@email.unc.edu
dataset submitter
Full Dataset Link List
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PRIDE project URI
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