<<< Full experiment listing

PXD011626

PXD011626 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleGenome-wide postnatal changes in immunity following fetal inflammatory response
DescriptionThe fetal inflammatory response (FIR) increases the risk of perinatal brain injury, particularly in extremely low gestational age newborns (ELGANs, < 28 weeks of gestation). One of the mechanisms contributing to such a risk is a postnatal intermittent or sustained systemic inflammation (ISSI) following FIR. The link between prenatal and postnatal systemic inflammation is supported by the presence of well-established inflammatory biomarkers in the umbilical cord and peripheral blood. However, the extent of molecular changes contributing to this association is unknown. Using RNA sequencing and mass spectrometry proteomics, we profiled the transcriptome and proteome of archived neonatal dried blood spot (DBS) specimens from 21 ELGANs. Comparing FIR-affected and unaffected ELGANs, we identified 782 gene and 27 protein expression changes of 50% magnitude or more, and an experiment-wide significance level below 5% false discovery rate. These expression changes confirm the robust postnatal activation of the innate immune system in FIR-affected ELGANs and reveal for the first time an impairment of their adaptive immunity. In turn, the altered pathway provide clues about the molecular mechanisms triggering ISSI after FIR, and the onset of perinatal brain injury.
HostingRepositoryPRIDE
AnnounceDate2021-01-04
AnnouncementXMLSubmission_2021-01-04_04:17:56.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterEduard Sabidó
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListmonohydroxylated residue; mono N-acetylated residue; iodoacetamide derivatized residue
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02018-11-08 03:34:37ID requested
12019-06-26 04:11:49announced
22020-12-23 04:53:49announced2020-12-23: Updated project metadata.
32020-12-23 05:02:16announced2020-12-23: Updated project metadata.
2020-12-23: Updated publication reference for PubMed record(s): 33006196.
42021-01-04 04:17:57announced2021-01-04: Updated project metadata.
Publication List
Costa D, Bonet N, Sol, é A, Gonz, á, lez de Aledo-Castillo JM, Sabid, ó E, Casals F, Rovira C, Nadal A, Marin JL, Cobo T, Castelo R, Genome-wide postnatal changes in immunity following fetal inflammatory response. FEBS J, 288(7):2311-2331(2021) [pubmed]
Keyword List
submitter keyword: Human, fetal inflammatory response, dried blood spots
Contact List
Eduard Sabidó
contact affiliationCenter for Genomic Regulation, Universitat Pompeu Fabra, 08003 Barcelona, Spain
contact emaileduard.sabido@crg.cat
lab head
Eduard Sabidó
contact affiliationCentre de Regulació Genòmica
contact emaileduard.sabido@crg.cat
dataset submitter
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/06/PXD011626
PRIDE project URI
Repository Record List
[ + ]