PXD011381

PXD011381 is an original dataset announced via ProteomeXchange.

Title	The role of ptpn21 in hematopoietic stem cells
Description	To identify the downstream substrate/effector that mediates Ptpn21 function. We applied comprehensive phosphoproteomics analysis with Lin- cells isolated from Ptpn21-/- and Ptpn21+/+ mice. The analysis revealed many pTyr sites on molecules associated with cytoskeleton. Additionally, we present a list of Ptpn21-dependent targets and putative substrates including Septin1 with increased tyrosine phosphorylation.
HostingRepository	iProX
AnnounceDate	2018-10-17
AnnouncementXML	Submission_2023-03-01_20:50:10.710.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Fang Ni
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2018-10-16 20:26:26	ID requested
1	2018-10-16 22:08:41	announced
⏵ 2	2023-03-01 20:50:14	announced	2023-03-02: Update publication information.

Ni F, Yu WM, Wang X, Fay ME, Young KM, Qiu Y, Lam WA, Sulchek TA, Cheng T, Scadden DT, Qu CK, Ptpn21 Controls Hematopoietic Stem Cell Homeostasis and Biomechanics. Cell Stem Cell, 24(4):608-620.e6(2019) [pubmed]

submitter keyword: ptpn21,biomechanics, septin1

Chengkui Qu
contact affiliation	Emory University
contact email	chengkui.qu@emory.edu
lab head
Fang Ni
contact affiliation	Emory University
contact email	fang.ni@emory.edu
dataset submitter

iProX dataset URI