PXD011348 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Oxygen effect on murine progenitor oligodrendrocytes |
Description | Hyperoxia is known to cause cerebral white matter injury in preterm infants with male sex being identified as an independent risk factor for poor neurodevelopmental outcome. We investigated the underlying mechanisms behind such a sex dependent difference by a comaparative protein profiling of male and female murine progenitor oligodendrocytes treated with 3 % or 80% oxygen. We demonstrate that following hyperoxia, the male derived oligodendrocyte progenitor cells (OPCs) are severely affected with respect to their energy metabolism, stress response and especially, maturation as compared to their female counterparts. |
HostingRepository | PRIDE |
AnnounceDate | 2021-09-08 |
AnnouncementXML | Submission_2021-09-08_07:29:57.052.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Elke Hammer |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | LTQ Orbitrap Velos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2018-10-12 05:34:47 | ID requested | |
⏵ 1 | 2021-09-08 07:30:00 | announced | |
Publication List
Sunny DE, Hammer E, Strempel S, Joseph C, Manchanda H, Ittermann T, H, ü, bner S, Weiss FU, V, ö, lker U, Heckmann M, mediate the differential effects of hyperoxia-induced damage in male and female OPCs. Mol Cell Pediatr, 7(1):10(2020) [pubmed] |
Keyword List
curator keyword: Biomedical |
submitter keyword: mouse brain, oxygen , LC-MS/MS |
Contact List
Elke Hammer |
contact affiliation | University Medicine Greifswald Department for Functional Genomics Felix-Hausdorff-Straße 8 17487 Greifswald |
contact email | hammer@uni-greifswald.de |
lab head | |
Elke Hammer |
contact affiliation | Dept. of Functional Genomics |
contact email | hammer@uni-greifswald.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
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[ - ]
- PRIDE
- PXD011348
- Label: PRIDE project
- Name: Oxygen effect on murine progenitor oligodrendrocytes