PXD011348

PXD011348 is an original dataset announced via ProteomeXchange.

Title	Oxygen effect on murine progenitor oligodrendrocytes
Description	Hyperoxia is known to cause cerebral white matter injury in preterm infants with male sex being identified as an independent risk factor for poor neurodevelopmental outcome. We investigated the underlying mechanisms behind such a sex dependent difference by a comaparative protein profiling of male and female murine progenitor oligodendrocytes treated with 3 % or 80% oxygen. We demonstrate that following hyperoxia, the male derived oligodendrocyte progenitor cells (OPCs) are severely affected with respect to their energy metabolism, stress response and especially, maturation as compared to their female counterparts.
HostingRepository	PRIDE
AnnounceDate	2021-09-08
AnnouncementXML	Submission_2021-09-08_07:29:57.052.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Elke Hammer
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2018-10-12 05:34:47	ID requested
⏵ 1	2021-09-08 07:30:00	announced

Sunny DE, Hammer E, Strempel S, Joseph C, Manchanda H, Ittermann T, H, ü, bner S, Weiss FU, V, ö, lker U, Heckmann M, mediate the differential effects of hyperoxia-induced damage in male and female OPCs. Mol Cell Pediatr, 7(1):10(2020) [pubmed]

curator keyword: Biomedical

submitter keyword: mouse brain, oxygen , LC-MS/MS

Elke Hammer
contact affiliation	University Medicine Greifswald Department for Functional Genomics Felix-Hausdorff-Straße 8 17487 Greifswald
contact email	hammer@uni-greifswald.de
lab head
Elke Hammer
contact affiliation	Dept. of Functional Genomics
contact email	hammer@uni-greifswald.de
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD011348
     1. Label: PRIDE project
     2. Name: Oxygen effect on murine progenitor oligodrendrocytes