PXD011195 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | VDAC2 promotes BAX apoptotic activity |
Description | Intrinsic apoptosis is critical for normal physiology including the prevention of tumor formation. BAX and BAK, which are essential for mediating this process and for the cytotoxic action of many anti-cancer drugs, are thought to be regulated through similar mechanisms and act redundantly to drive apoptosis. Here we have established the various mitochondrial complexes that contain VDAC1, VDAC2, VDAC3 and BAX or BAK. |
HostingRepository | PRIDE |
AnnounceDate | 2018-10-29 |
AnnouncementXML | Submission_2018-10-29_07:24:30.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Laura Dagley |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive; Bruker Daltonics micrOTOF series |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2018-09-27 01:55:39 | ID requested | |
⏵ 1 | 2018-10-29 07:24:31 | announced | |
2 | 2018-12-05 07:51:30 | announced | Updated publication reference for PubMed record(s): 30478310. |
Publication List
Dataset with its publication pending |
Keyword List
curator keyword: Biological |
submitter keyword: Apoptosis, BAX, BAK, BCL-2, cancer, mitochondria, voltage-dependent anion channel. |
Contact List
Grant Dewson |
contact affiliation | Laboratory head, Cell Death and Cell Signalling Division, WEHI, Australia |
contact email | dewson@wehi.edu.au |
lab head | |
Laura Dagley |
contact affiliation | WEHI |
contact email | dagley.l@wehi.edu.au |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD011195
- Label: PRIDE project
- Name: VDAC2 promotes BAX apoptotic activity