PXD011195

PXD011195 is an original dataset announced via ProteomeXchange.

Title	VDAC2 promotes BAX apoptotic activity
Description	Intrinsic apoptosis is critical for normal physiology including the prevention of tumor formation. BAX and BAK, which are essential for mediating this process and for the cytotoxic action of many anti-cancer drugs, are thought to be regulated through similar mechanisms and act redundantly to drive apoptosis. Here we have established the various mitochondrial complexes that contain VDAC1, VDAC2, VDAC3 and BAX or BAK.
HostingRepository	PRIDE
AnnounceDate	2018-10-29
AnnouncementXML	Submission_2018-12-05_07:51:28.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Laura Dagley
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive; Bruker Daltonics micrOTOF series

Revision	Datetime	Status	ChangeLog Entry
0	2018-09-27 01:55:39	ID requested
1	2018-10-29 07:24:31	announced
⏵ 2	2018-12-05 07:51:30	announced	Updated publication reference for PubMed record(s): 30478310.

Chin HS, Li MX, Tan IKL, Ninnis RL, Reljic B, Scicluna K, Dagley LF, Sandow JJ, Kelly GL, Samson AL, Chappaz S, Khaw SL, Chang C, Morokoff A, Brinkmann K, Webb A, Hockings C, Hall CM, Kueh AJ, Ryan MT, Kluck RM, Bouillet P, Herold MJ, Gray DHD, Huang DCS, van Delft MF, Dewson G, VDAC2 enables BAX to mediate apoptosis and limit tumor development. Nat Commun, 9(1):4976(2018) [pubmed]

curator keyword: Biological

submitter keyword: Apoptosis, BAX, BAK, BCL-2, cancer, mitochondria, voltage-dependent anion channel.

Grant Dewson
contact affiliation	Laboratory head, Cell Death and Cell Signalling Division, WEHI, Australia
contact email	dewson@wehi.edu.au
lab head
Laura Dagley
contact affiliation	WEHI
contact email	dagley.l@wehi.edu.au
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/10/PXD011195

PRIDE project URI

• PRIDE
  1. PXD011195
     1. Label: PRIDE project
     2. Name: VDAC2 promotes BAX apoptotic activity