PXD010540 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | An atypical parvovirus driving chronic tubulointerstitial nephropathy and kidney fibrosis |
Description | The occurrence of a spontaneous nephropathy in laboratory mice, characterized by tubular degeneration and intranuclear inclusions, has puzzled pathologists for over four decades. While the condition takes a more severe course in immunodeficient animals suggesting an infectious cause, its etiology has remained elusive. Using an unbiased metagenomics approach, we have identified the causative agent as a novel virus, mouse kidney parvovirus (MKPV), belonging to a divergent and unclassified genus of the Parvoviridae. MKPV was found to be present in animal facilities in Australia and North America, is transmitted via the orofecal route and is controlled by the adaptive immune system. Detailed analysis of the clinical course and histopathologic features demonstrated a stepwise progression of pathology ranging from sporadic tubular inclusions to extensive tubular degeneration and interstitial fibrosis culminating in renal failure. In summary, we identify a novel, widely distributed pathogen in laboratory mice causing significant impact on the interpretation and outcome of biomedical research based on mouse models. Additionally, we establish MKPV-induced nephropathy as a new tool for elucidating the mechanisms of tubulointerstitial fibrosis that shares molecular features with chronic kidney disease in humans. |
HostingRepository | PRIDE |
AnnounceDate | 2018-09-06 |
AnnouncementXML | Submission_2018-09-06_06:46:59.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | matthew O'Rourke |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2018-07-24 01:58:55 | ID requested | |
⏵ 1 | 2018-09-06 06:46:59 | announced | |
2 | 2018-09-19 03:55:06 | announced | Updated publication reference for PubMed record(s): 30220458. |
3 | 2018-12-04 03:52:39 | announced | Updated project metadata. |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Miouse, Liver, Proteomics, Virus |
Contact List
Ben Roediger |
contact affiliation | Centenary Institute, Newtown, New South Wales, Australia |
contact email | b.roediger@centenary.org.au |
lab head | |
matthew O'Rourke |
contact affiliation | University of Sydney |
contact email | matthew.orourke1@gmail.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD010540
- Label: PRIDE project
- Name: An atypical parvovirus driving chronic tubulointerstitial nephropathy and kidney fibrosis