PXD010245 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Mononuclear phagocyte phenotypes in a multiple sclerosis model |
Description | Mononuclear phagocytes are key regulators of both tissue damage and repair in neuroinflammatory conditions such as multiple sclerosis (MS). To examine divergent phagocyte phenotypes in the inflamed central nervous system (CNS) we introduce an in vivo imaging approach combined with RNAseq and proteomics that allows us to temporally and spatially resolve the evolution of phagocyte polarization in a murine MS model. We show that the initial pro-inflammatory polarization of phagocytes is established after spinal cord entry and critically depends on the compartment they enter. Guided by signals from the CNS environment individual phagocytes then switch their phenotype as lesions move from expansion to resolution. Our study thus provides a first real-time analysis of the temporo-spatial determinants and regulatory principles of phagocyte specification in the inflamed CNS. |
HostingRepository | PRIDE |
AnnounceDate | 2019-07-10 |
AnnouncementXML | Submission_2019-07-10_01:28:58.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | kshiti phulphagar |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2018-06-27 03:56:42 | ID requested | |
⏵ 1 | 2019-07-10 01:28:59 | announced | |
Publication List
Locatelli G, Theodorou D, Kendirli A, Jord, ã, o MJC, Staszewski O, Phulphagar K, Cantuti-Castelvetri L, Dagkalis A, Bessis A, Simons M, Meissner F, Prinz M, Kerschensteiner M, Mononuclear phagocytes locally specify and adapt their phenotype in a multiple sclerosis model. Nat Neurosci, 21(9):1196-1208(2018) [pubmed] |
Keyword List
curator keyword: Biological, Biomedical |
submitter keyword: Mononuclear pahgocytes, multiple sclerosis, macrophage, microglia, central nervous system, experimental autoimmune encephalomyelitis |
Contact List
Dr. Felix Meissner, PhD |
contact affiliation | Independent Research group Leader Experimental Systems Immunology Max Planck insitute of Biochemistry Martinsried, Germany |
contact email | meissner@biochem.mpg.de |
lab head | |
kshiti phulphagar |
contact affiliation | Max Planck Institute of Biochemistry |
contact email | phulphagar@biochem.mpg.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/07/PXD010245 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD010245
- Label: PRIDE project
- Name: Mononuclear phagocyte phenotypes in a multiple sclerosis model