PXD010245

PXD010245 is an original dataset announced via ProteomeXchange.

Title	Mononuclear phagocyte phenotypes in a multiple sclerosis model
Description	Mononuclear phagocytes are key regulators of both tissue damage and repair in neuroinflammatory conditions such as multiple sclerosis (MS). To examine divergent phagocyte phenotypes in the inflamed central nervous system (CNS) we introduce an in vivo imaging approach combined with RNAseq and proteomics that allows us to temporally and spatially resolve the evolution of phagocyte polarization in a murine MS model. We show that the initial pro-inflammatory polarization of phagocytes is established after spinal cord entry and critically depends on the compartment they enter. Guided by signals from the CNS environment individual phagocytes then switch their phenotype as lesions move from expansion to resolution. Our study thus provides a first real-time analysis of the temporo-spatial determinants and regulatory principles of phagocyte specification in the inflamed CNS.
HostingRepository	PRIDE
AnnounceDate	2019-07-10
AnnouncementXML	Submission_2019-07-10_01:28:58.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	kshiti phulphagar
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2018-06-27 03:56:42	ID requested
⏵ 1	2019-07-10 01:28:59	announced

Locatelli G, Theodorou D, Kendirli A, Jord, ã, o MJC, Staszewski O, Phulphagar K, Cantuti-Castelvetri L, Dagkalis A, Bessis A, Simons M, Meissner F, Prinz M, Kerschensteiner M, Mononuclear phagocytes locally specify and adapt their phenotype in a multiple sclerosis model. Nat Neurosci, 21(9):1196-1208(2018) [pubmed]

curator keyword: Biological, Biomedical

submitter keyword: Mononuclear pahgocytes, multiple sclerosis, macrophage, microglia, central nervous system, experimental autoimmune encephalomyelitis

Dr. Felix Meissner, PhD
contact affiliation	Independent Research group Leader Experimental Systems Immunology Max Planck insitute of Biochemistry Martinsried, Germany
contact email	meissner@biochem.mpg.de
lab head
kshiti phulphagar
contact affiliation	Max Planck Institute of Biochemistry
contact email	phulphagar@biochem.mpg.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/07/PXD010245

PRIDE project URI

• PRIDE
  1. PXD010245
     1. Label: PRIDE project
     2. Name: Mononuclear phagocyte phenotypes in a multiple sclerosis model