PXD009780 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Autocrine Motility Factor Modulates Proliferation Signaling Mediated By GPER |
Description | Traditional surgery plus radiotherapy or chemotherapy, existing targeted therapies failed to significantly improve the survival rate of recurrent endometrial cancer, so suggesting that mechanism of recurrence and progression that modulates in endometrial cancer is clinically important. Here, we show that GPER(G protein-coupled estrogen receptor 1) was binded to AMF, and the complex were translocation form plasma to cytoplasmic. Mechanistic investigations elucidated that interaction of AMF with GPER triggers phosphoinositide-3-kinase (PI3K) signaling activating and accelerating the ability of endometrial cancer cells growth. Furthermore, we found that AMF may contribute to GPER-mediated endometrial cancer progression using animal experiments and human histological experiments which be consistent with the above conclusions. On the basis of these evidences including invivo and invitro, our findings suggest that AMF–GPER interaction might be novel key molecular targets for therapeutic management of patients with endometrial cancer, whose disease were progression and recurrence. |
HostingRepository | PRIDE |
AnnounceDate | 2019-03-12 |
AnnouncementXML | Submission_2019-03-11_18:31:39.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Yiran Li |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | iTRAQ8plex-116 reporter+balance reagent acylated residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2018-05-15 01:50:48 | ID requested | |
⏵ 1 | 2019-03-11 18:31:40 | announced | |
Publication List
Li Y, Jia Y, Bian Y, Tong H, Qu J, Wang K, Wan XP, Autocrine motility factor promotes endometrial cancer progression by targeting GPER-1. Cell Commun Signal, 17(1):22(2019) [pubmed] |
Keyword List
curator keyword: Biomedical |
submitter keyword: human,endometrial cancer |
Contact List
xiaoping wan |
contact affiliation | No.2699, Gaoke West Road, Pudong New Area, Shanghai |
contact email | wanxiaoping61@126.com |
lab head | |
Yiran Li |
contact affiliation | yiran_eric@126.com |
contact email | yiran_eric@126.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD009780
- Label: PRIDE project
- Name: Autocrine Motility Factor Modulates Proliferation Signaling Mediated By GPER