PXD009780

PXD009780 is an original dataset announced via ProteomeXchange.

Title	Autocrine Motility Factor Modulates Proliferation Signaling Mediated By GPER
Description	Traditional surgery plus radiotherapy or chemotherapy, existing targeted therapies failed to significantly improve the survival rate of recurrent endometrial cancer, so suggesting that mechanism of recurrence and progression that modulates in endometrial cancer is clinically important. Here, we show that GPER(G protein-coupled estrogen receptor 1) was binded to AMF, and the complex were translocation form plasma to cytoplasmic. Mechanistic investigations elucidated that interaction of AMF with GPER triggers phosphoinositide-3-kinase (PI3K) signaling activating and accelerating the ability of endometrial cancer cells growth. Furthermore, we found that AMF may contribute to GPER-mediated endometrial cancer progression using animal experiments and human histological experiments which be consistent with the above conclusions. On the basis of these evidences including invivo and invitro, our findings suggest that AMF–GPER interaction might be novel key molecular targets for therapeutic management of patients with endometrial cancer, whose disease were progression and recurrence.
HostingRepository	PRIDE
AnnounceDate	2019-03-12
AnnouncementXML	Submission_2019-03-11_18:31:39.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yiran Li
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iTRAQ8plex-116 reporter+balance reagent acylated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2018-05-15 01:50:48	ID requested
⏵ 1	2019-03-11 18:31:40	announced

Li Y, Jia Y, Bian Y, Tong H, Qu J, Wang K, Wan XP, Autocrine motility factor promotes endometrial cancer progression by targeting GPER-1. Cell Commun Signal, 17(1):22(2019) [pubmed]

curator keyword: Biomedical

submitter keyword: human,endometrial cancer

xiaoping wan
contact affiliation	No.2699, Gaoke West Road, Pudong New Area, Shanghai
contact email	wanxiaoping61@126.com
lab head
Yiran Li
contact affiliation	yiran_eric@126.com
contact email	yiran_eric@126.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/03/PXD009780

PRIDE project URI

• PRIDE
  1. PXD009780
     1. Label: PRIDE project
     2. Name: Autocrine Motility Factor Modulates Proliferation Signaling Mediated By GPER