PXD009659 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | A survival mechanism controlled by cadherins and Dlg1 polarity complex inhibits Fas cell death receptor signaling |
Description | A fine regulation of epithelia cell death is required to maintain tissue integrity and homeostasis. At a cellular level, this life and death decision is controlled by environmental stimuli including death receptors activation. Here, we show that establishment of cell polarity and AJ formation control the pro-apoptotic signaling emanating from the death receptor Fas. We demonstrate that in colon epithelia Fas concentrates at cell-cell junctions together with the E-cadherin, which protects cells from FasL-induced cell death. The Fas-cadherin association requires the C terminal PDZ binding site of Fas and, using a proteomic approach, we showed that this domain allows the association with the polarity molecule Dlg1. We proved that the interaction of Fas with this scaffold molecule participate to this cell death protection. Therefore inhibition of FasL-induced cell death by Fas-cadherin-Dlg1 complex is a double-edged sword mechanism that helps to maintain epithelial homeostasis by (i) protecting normal polarized epithelia from apoptosis (ii) promoting the elimination of compromised non-polarized cells. |
HostingRepository | PRIDE |
AnnounceDate | 2018-09-20 |
AnnouncementXML | Submission_2018-09-20_05:09:27.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | AUDEBERT Stephane |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | iodoacetamide derivatized residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2018-05-03 01:42:50 | ID requested | |
⏵ 1 | 2018-09-20 05:09:28 | announced | |
2 | 2021-05-27 21:56:45 | announced | 2021-05-28: Updated publication reference for PubMed record(s): 30242034. |
Publication List
Dataset with its publication pending |
Keyword List
curator keyword: Biological |
submitter keyword: Human, LC-MSMS, PDZ, cell Polarity, epithelia, cell death, death receptor |
Contact List
Audebert Stephane |
contact affiliation | Centre de Recherche en Cancérologie de Marseille, CRCM Inserm UMR1068, CNRS UMR7258, Aix Marseille Université U105, Institut Paoli Calmettes 27 Boulevard Leï Roure CS30059 13273 Marseille Cedex 09 France |
contact email | stephane.audebert@inserm.fr |
lab head | |
AUDEBERT Stephane |
contact affiliation | Pharmacology department |
contact email | stephane.audebert@inserm.fr |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD009659
- Label: PRIDE project
- Name: A survival mechanism controlled by cadherins and Dlg1 polarity complex inhibits Fas cell death receptor signaling